FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382777245> ?p ?o ?g. }

• W4382777245 abstract "Abstract Background Systemic lupus erythematosus (SLE) is a clinically and biologically heterogeneous autoimmune disease. We explored whether the deconvolution of whole blood transcriptomic data could identify differences in predicted immune cell frequency between active SLE patients, and whether these differences are associated with clinical features and/or medication use. Methods Patients with active SLE (BILAG-2004 Index) enrolled in the BILAG-Biologics Registry (BILAG-BR), prior to change in therapy, were studied as part of the MASTERPLANS Stratified Medicine consortium. Whole blood RNA-sequencing (RNA-seq) was conducted at enrolment into the registry. Data were deconvoluted using CIBERSORTx. Predicted immune cell frequencies were compared between active and inactive disease in the nine BILAG-2004 domains and according to immunosuppressant use (current and past). Results Predicted cell frequency varied between 109 patients. Patients currently, or previously, exposed to mycophenolate mofetil (MMF) had fewer inactivated macrophages (0.435% vs 1.391%, p = 0.001), naïve CD4 T cells (0.961% vs 2.251%, p = 0.002), and regulatory T cells (1.858% vs 3.574%, p = 0.007), as well as a higher proportion of memory activated CD4 T cells (1.826% vs 1.113%, p = 0.015), compared to patients never exposed to MMF. These differences remained statistically significant after adjusting for age, gender, ethnicity, disease duration, renal disease, and corticosteroid use. There were 2607 differentially expressed genes (DEGs) in patients exposed to MMF with over-representation of pathways relating to eosinophil function and erythrocyte development and function. Within CD4 + T cells, there were fewer predicted DEGs related to MMF exposure. No significant differences were observed for the other conventional immunosuppressants nor between patients according disease activity in any of the nine organ domains. Conclusion MMF has a significant and persisting effect on the whole blood transcriptomic signature in patients with SLE. This highlights the need to adequately adjust for background medication use in future studies using whole blood transcriptomics." @default.
• W4382777245 created "2023-07-02" @default.
• W4382777245 creator A5000205562 @default.
• W4382777245 creator A5014266328 @default.
• W4382777245 creator A5023290270 @default.
• W4382777245 creator A5029115990 @default.
• W4382777245 creator A5040192632 @default.
• W4382777245 creator A5066721628 @default.
• W4382777245 creator A5071079442 @default.
• W4382777245 creator A5071947542 @default.
• W4382777245 date "2023-06-30" @default.
• W4382777245 modified "2023-10-07" @default.
• W4382777245 title "Deconvolution of whole blood transcriptomics identifies changes in immune cell composition in patients with systemic lupus erythematosus (SLE) treated with mycophenolate mofetil" @default.
• W4382777245 cites W1795316817 @default.
• W4382777245 cites W1985987855 @default.
• W4382777245 cites W2007180014 @default.
• W4382777245 cites W2043454321 @default.
• W4382777245 cites W2069561504 @default.
• W4382777245 cites W2070527591 @default.
• W4382777245 cites W2073745127 @default.
• W4382777245 cites W2081920281 @default.
• W4382777245 cites W2131271579 @default.
• W4382777245 cites W2131569300 @default.
• W4382777245 cites W2159860161 @default.
• W4382777245 cites W2168146874 @default.
• W4382777245 cites W2169456326 @default.
• W4382777245 cites W2179438025 @default.
• W4382777245 cites W2270331376 @default.
• W4382777245 cites W2788142646 @default.
• W4382777245 cites W2904430253 @default.
• W4382777245 cites W2905102681 @default.
• W4382777245 cites W2942610007 @default.
• W4382777245 cites W2955822319 @default.
• W4382777245 cites W2982003071 @default.
• W4382777245 cites W3046387576 @default.
• W4382777245 cites W3047054183 @default.
• W4382777245 cites W3047170019 @default.
• W4382777245 cites W3123168575 @default.
• W4382777245 cites W3127477811 @default.
• W4382777245 cites W3140147412 @default.
• W4382777245 cites W3198427233 @default.
• W4382777245 cites W3202027727 @default.
• W4382777245 cites W4211146151 @default.
• W4382777245 cites W4292113792 @default.
• W4382777245 doi "https://doi.org/10.1186/s13075-023-03089-5" @default.
• W4382777245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37391799" @default.
• W4382777245 hasPublicationYear "2023" @default.
• W4382777245 type Work @default.
• W4382777245 citedByCount "1" @default.
• W4382777245 countsByYear W43827772452023 @default.
• W4382777245 crossrefType "journal-article" @default.
• W4382777245 hasAuthorship W4382777245A5000205562 @default.
• W4382777245 hasAuthorship W4382777245A5014266328 @default.
• W4382777245 hasAuthorship W4382777245A5023290270 @default.
• W4382777245 hasAuthorship W4382777245A5029115990 @default.
• W4382777245 hasAuthorship W4382777245A5040192632 @default.
• W4382777245 hasAuthorship W4382777245A5066721628 @default.
• W4382777245 hasAuthorship W4382777245A5071079442 @default.
• W4382777245 hasAuthorship W4382777245A5071947542 @default.
• W4382777245 hasBestOaLocation W43827772451 @default.
• W4382777245 hasConcept C126322002 @default.
• W4382777245 hasConcept C198451711 @default.
• W4382777245 hasConcept C203014093 @default.
• W4382777245 hasConcept C2776090121 @default.
• W4382777245 hasConcept C2776912625 @default.
• W4382777245 hasConcept C2777575956 @default.
• W4382777245 hasConcept C2779134260 @default.
• W4382777245 hasConcept C2909935303 @default.
• W4382777245 hasConcept C2911091166 @default.
• W4382777245 hasConcept C71924100 @default.
• W4382777245 hasConcept C8891405 @default.
• W4382777245 hasConceptScore W4382777245C126322002 @default.
• W4382777245 hasConceptScore W4382777245C198451711 @default.
• W4382777245 hasConceptScore W4382777245C203014093 @default.
• W4382777245 hasConceptScore W4382777245C2776090121 @default.
• W4382777245 hasConceptScore W4382777245C2776912625 @default.
• W4382777245 hasConceptScore W4382777245C2777575956 @default.
• W4382777245 hasConceptScore W4382777245C2779134260 @default.
• W4382777245 hasConceptScore W4382777245C2909935303 @default.
• W4382777245 hasConceptScore W4382777245C2911091166 @default.
• W4382777245 hasConceptScore W4382777245C71924100 @default.
• W4382777245 hasConceptScore W4382777245C8891405 @default.
• W4382777245 hasIssue "1" @default.
• W4382777245 hasLocation W43827772451 @default.
• W4382777245 hasLocation W43827772452 @default.
• W4382777245 hasLocation W43827772453 @default.
• W4382777245 hasOpenAccess W4382777245 @default.
• W4382777245 hasPrimaryLocation W43827772451 @default.
• W4382777245 hasRelatedWork W2045151582 @default.
• W4382777245 hasRelatedWork W2076597215 @default.
• W4382777245 hasRelatedWork W2082406232 @default.
• W4382777245 hasRelatedWork W2156283049 @default.
• W4382777245 hasRelatedWork W2316954211 @default.
• W4382777245 hasRelatedWork W2326094713 @default.
• W4382777245 hasRelatedWork W2427075784 @default.
• W4382777245 hasRelatedWork W2617939361 @default.
• W4382777245 hasRelatedWork W2761967325 @default.
• W4382777245 hasRelatedWork W4210646529 @default.
• W4382777245 hasVolume "25" @default.
• W4382777245 isParatext "false" @default.

• next