FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382777413> ?p ?o ?g. }

• W4382777413 endingPage "2366" @default.
• W4382777413 startingPage "2353" @default.
• W4382777413 abstract "Telomerase, telomeric DNA and associated proteins together represent a complex, finely tuned and functionally conserved mechanism that ensures genome integrity by protecting and maintaining chromosome ends. Changes in its components can threaten an organism's viability. Nevertheless, molecular innovation in telomere maintenance has occurred multiple times during eukaryote evolution, giving rise to species/taxa with unusual telomeric DNA sequences, telomerase components or telomerase-independent telomere maintenance. The central component of telomere maintenance machinery is telomerase RNA (TR) as it templates telomere DNA synthesis, its mutation can change telomere DNA and disrupt its recognition by telomere proteins, thereby leading to collapse of their end-protective and telomerase recruitment functions. Using a combination of bioinformatic and experimental approaches, we examine a plausible scenario of evolutionary changes in TR underlying telomere transitions. We identified plants harbouring multiple TR paralogs whose template regions could support the synthesis of diverse telomeres. In our hypothesis, formation of unusual telomeres is associated with the occurrence of TR paralogs that can accumulate mutations, and through their functional redundancy, allow for the adaptive evolution of the other telomere components. Experimental analyses of telomeres in the examined plants demonstrate evolutionary telomere transitions corresponding to TR paralogs with diverse template regions." @default.
• W4382777413 created "2023-07-02" @default.
• W4382777413 creator A5001954580 @default.
• W4382777413 creator A5009890458 @default.
• W4382777413 creator A5010138240 @default.
• W4382777413 creator A5015384537 @default.
• W4382777413 creator A5025921759 @default.
• W4382777413 creator A5026876401 @default.
• W4382777413 creator A5032578926 @default.
• W4382777413 creator A5036893134 @default.
• W4382777413 creator A5042927463 @default.
• W4382777413 creator A5053563084 @default.
• W4382777413 creator A5068262865 @default.
• W4382777413 creator A5074823226 @default.
• W4382777413 creator A5092373724 @default.
• W4382777413 date "2023-06-30" @default.
• W4382777413 modified "2023-10-18" @default.
• W4382777413 title "Telomerase <scp>RNA</scp> gene paralogs in plants – the usual pathway to unusual telomeres" @default.
• W4382777413 cites W2003527548 @default.
• W4382777413 cites W2022957238 @default.
• W4382777413 cites W2024299931 @default.
• W4382777413 cites W2045515755 @default.
• W4382777413 cites W2060016605 @default.
• W4382777413 cites W2062344134 @default.
• W4382777413 cites W2063048131 @default.
• W4382777413 cites W2067086660 @default.
• W4382777413 cites W2080131415 @default.
• W4382777413 cites W2083884012 @default.
• W4382777413 cites W2112814753 @default.
• W4382777413 cites W2126419817 @default.
• W4382777413 cites W2141152740 @default.
• W4382777413 cites W2142678478 @default.
• W4382777413 cites W2146384771 @default.
• W4382777413 cites W2147504242 @default.
• W4382777413 cites W2152839865 @default.
• W4382777413 cites W2160636499 @default.
• W4382777413 cites W2165751370 @default.
• W4382777413 cites W2167279371 @default.
• W4382777413 cites W2179444328 @default.
• W4382777413 cites W2187655481 @default.
• W4382777413 cites W2202675211 @default.
• W4382777413 cites W2474358581 @default.
• W4382777413 cites W2511260145 @default.
• W4382777413 cites W2752852083 @default.
• W4382777413 cites W2918361769 @default.
• W4382777413 cites W2968687555 @default.
• W4382777413 cites W2990427812 @default.
• W4382777413 cites W2995427011 @default.
• W4382777413 cites W3037025673 @default.
• W4382777413 cites W3092076961 @default.
• W4382777413 cites W3114908820 @default.
• W4382777413 cites W3136195778 @default.
• W4382777413 cites W3137947458 @default.
• W4382777413 cites W3169099050 @default.
• W4382777413 cites W3173380437 @default.
• W4382777413 cites W3180739613 @default.
• W4382777413 cites W4229487902 @default.
• W4382777413 cites W4232644640 @default.
• W4382777413 cites W4237467716 @default.
• W4382777413 cites W4281680886 @default.
• W4382777413 cites W4293247451 @default.
• W4382777413 cites W4312077137 @default.
• W4382777413 doi "https://doi.org/10.1111/nph.19110" @default.
• W4382777413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37391893" @default.
• W4382777413 hasPublicationYear "2023" @default.
• W4382777413 type Work @default.
• W4382777413 citedByCount "2" @default.
• W4382777413 countsByYear W43827774132023 @default.
• W4382777413 crossrefType "journal-article" @default.
• W4382777413 hasAuthorship W4382777413A5001954580 @default.
• W4382777413 hasAuthorship W4382777413A5009890458 @default.
• W4382777413 hasAuthorship W4382777413A5010138240 @default.
• W4382777413 hasAuthorship W4382777413A5015384537 @default.
• W4382777413 hasAuthorship W4382777413A5025921759 @default.
• W4382777413 hasAuthorship W4382777413A5026876401 @default.
• W4382777413 hasAuthorship W4382777413A5032578926 @default.
• W4382777413 hasAuthorship W4382777413A5036893134 @default.
• W4382777413 hasAuthorship W4382777413A5042927463 @default.
• W4382777413 hasAuthorship W4382777413A5053563084 @default.
• W4382777413 hasAuthorship W4382777413A5068262865 @default.
• W4382777413 hasAuthorship W4382777413A5074823226 @default.
• W4382777413 hasAuthorship W4382777413A5092373724 @default.
• W4382777413 hasBestOaLocation W43827774131 @default.
• W4382777413 hasConcept C104317684 @default.
• W4382777413 hasConcept C125593758 @default.
• W4382777413 hasConcept C141231307 @default.
• W4382777413 hasConcept C177336024 @default.
• W4382777413 hasConcept C202265312 @default.
• W4382777413 hasConcept C2779413310 @default.
• W4382777413 hasConcept C34558173 @default.
• W4382777413 hasConcept C54355233 @default.
• W4382777413 hasConcept C552990157 @default.
• W4382777413 hasConcept C67705224 @default.
• W4382777413 hasConcept C70721500 @default.
• W4382777413 hasConcept C86339819 @default.
• W4382777413 hasConcept C86803240 @default.
• W4382777413 hasConcept C94581717 @default.
• W4382777413 hasConcept C94966510 @default.

• next