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- W4382786314 abstract "Interleukin (IL)-26 is a TH17 cytokine with known antimicrobial and pro-inflammatory functions. However, the precise role of IL-26 in the context of pathogenic TH17 responses is unknown. Here we identify a population of blood TH17 intermediates that produce high levels of IL-26 and differentiate into IL-17A-producing TH17 cells upon TGF-β1 exposure. By combining single cell RNA sequencing, TCR sequencing and spatial transcriptomics we show that this process occurs in psoriatic skin. In fact, IL-26+ TH17 intermediates infiltrating psoriatic skin induce TGF-β1 expression in basal keratinocytes and thereby promote their own differentiation into IL-17A-producing cells. Thus, our study identifies IL-26-producing cells as an early differentiation stage of TH17 cells that infiltrates psoriatic skin and controls its own maturation into IL17A-producing TH17 cells, via epithelial crosstalk involving paracrine production of TGF-β1." @default.
- W4382786314 created "2023-07-02" @default.
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- W4382786314 date "2023-06-30" @default.
- W4382786314 modified "2023-10-15" @default.
- W4382786314 title "Differentiation of IL-26+ TH17 intermediates into IL-17A producers via epithelial crosstalk in psoriasis" @default.
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- W4382786314 doi "https://doi.org/10.1038/s41467-023-39484-4" @default.
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