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- W4382788963 endingPage "3421" @default.
- W4382788963 startingPage "3421" @default.
- W4382788963 abstract "Glioma is the most aggressive malignant tumor of the central nervous system, and most patients suffer from a recurrence. Unfortunately, recurrent glioma often becomes resistant to established chemotherapy and radiotherapy treatments. Immunotherapy, a rapidly developing anti-tumor therapy, has shown a potential value in treating recurrent glioma. Multiple immune strategies have been explored. The most-used ones are immune checkpoint blockade (ICB) antibodies, which are barely effective in monotherapy. However, when combined with other immunotherapy, especially with anti-angiogenesis antibodies, ICB has shown encouraging efficacy and enhanced anti-tumor immune response. Oncolytic viruses and CAR-T therapies have shown promising results in recurrent glioma through multiple mechanisms. Vaccination strategies and immune-cell-based immunotherapies are promising in some subgroups of patients, and multiple new tumor antigenic targets have been discovered. In this review, we discuss current applicable immunotherapies and related mechanisms for recurrent glioma, focusing on multiple preclinical models and clinical trials in the last 5 years. Through reviewing the current combination of immune strategies, we would like to provide substantive thoughts for further novel therapeutic regimes treating recurrent glioma." @default.
- W4382788963 created "2023-07-02" @default.
- W4382788963 creator A5001104689 @default.
- W4382788963 creator A5038978522 @default.
- W4382788963 creator A5041129342 @default.
- W4382788963 creator A5044423965 @default.
- W4382788963 creator A5090164349 @default.
- W4382788963 date "2023-06-30" @default.
- W4382788963 modified "2023-10-17" @default.
- W4382788963 title "Immunotherapy for Recurrent Glioma—From Bench to Bedside" @default.
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