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- W4382795357 abstract "AimThe aim of the study was to study clinical profile of ACLF and establish cell free DNA as a predictor of the outcome of ACLF.MethodsIn this prospective study, those patients who fulfilled EASL criteria were included. Cell free DNA (Cf DNA) was estimated in 30 patients and compared with CLIF-C ACLF score.ResultsThe median age of 132 consecutive ACLF patients was 40 years. The most common acute insult was sepsis (30.3%) and alcohol (22%). While alcohol (35.6%) and chronic HBV (14.3%) were the most common etiology of cirrhosis. The overall mortality was 45.5% and 71.2% at 28-days and 90-days respectively. Multiple regression analysis using the Cox proportional hazard model showed that heart rate (HR 1.06, 95% CI 1.04-1.08 P=0.001), lung failure (HR 2.82, 95% CI 1.24-6.44, P=0.02) and cell-free DNA (HR 2.70, 95% CI 1.17- 6.24, P = 0.02), were independent predictors of mortality When CfDNA was used to predict 28 days mortality, CfDNA was found to have a higher AUC (AUROC 0.84, 95% CI 0.70-.98, P=0.001) than the CLIF-C-ACLF score (AUROC 0.81, 95% 0.66-0.97, P=0.003). However, when 90 days mortality was compared, CLIF-C-ACLF score had a higher area under the curve (AUROC 0.93, 95% CI 0.83-1.00, P=0.0001) than CfDNA (AUROC 0.89, 95% CI 0.77-1.00, P=0.0001).ConclusionsAlcohol and sepsis remains most common causes of acute insult. Cf DNA is a better predictor of 28 days mortality where as CLIF-C ACLF is more accurate to predict 90 days mortality." @default.
- W4382795357 created "2023-07-02" @default.
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- W4382795357 date "2023-07-01" @default.
- W4382795357 modified "2023-10-14" @default.
- W4382795357 title "Clinical Profile and Prognostic Markers of Acute on Chronic Liver Failure (ACLF): A Single-center Experience from East India" @default.
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- W4382795357 doi "https://doi.org/10.1016/j.jceh.2023.06.010" @default.
- W4382795357 hasPublicationYear "2023" @default.
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