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• W4382796648 abstract "Abstract Protein complexes are pivotal to most cellular processes. Emerging evidence indicates that pairs of ribosomes ubiquitously drive the synchronized synthesis and assembly of two protein subunits into homodimeric complexes 1-5 . These observations suggest protein folding mechanisms of general importance enabled by contacts between nascent chains 6,7 – which have thus far rather been considered detrimental 8,9 . However, owing to their dynamic and heterogeneous nature, the folding of interacting nascent chains remains unexplored. Here, we show that co-translational ribosome pairing allows their nascent chains to ‘chaperone each other’, thus enabling the formation of coiled-coil homodimers from subunits that misfold individually. We developed an integrated single-molecule fluorescence and force spectroscopy approach to probe the folding and assembly of two nascent chains extending from nearby ribosomes, using the intermediate filament lamin as a model system. Ribosome proximity in early translation stages was found to be critical: when interactions between nascent chains are inhibited or delayed, they become trapped in stable misfolded states that are no longer assembly competent. Conversely, early interactions allow the two nascent chains to nucleate native-like quaternary structures that grow in size and stability as translation advances. We conjecture that protein folding mechanisms enabled by ribosome cooperation are more broadly relevant to intermediate filaments and other protein classes." @default.
• W4382796648 created "2023-07-02" @default.
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• W4382796648 date "2023-06-30" @default.
• W4382796648 modified "2023-10-14" @default.
• W4382796648 title "Co-translational ribosome pairing enables native assembly of misfolding-prone subunits" @default.
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• W4382796648 doi "https://doi.org/10.1101/2023.06.30.547139" @default.
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