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• W4382796757 abstract "Prediabetes is a state of hyperglycemia between normal and diabetes, in which individuals are at increased risk of progression to type 2 diabetes (T2D). The conversion rate of prediabetes to T2D is 7 % in the first year and 13 % within 2 years according to a cohort study among 14,272 participants in the United Kingdom [ [9] Ravindrarajah R. et al. Epidemiology and determinants of non-diabetic hyperglycaemia and its conversion to type 2 diabetes mellitus, 2000–2015: cohort population study using UK electronic health records. BMJ Open. 2020; 10e040201 Crossref PubMed Scopus (9) Google Scholar ]. Comparable figure of about 10 % conversion rate per year is reported in the United States [ [4] Echouffo-Tcheugui J.B. Perreault L. Ji L. Dagogo-Jack S. Diagnosis and management of prediabetes: a review. JAMA. 2023; 329: 1206-1216 Crossref PubMed Scopus (3) Google Scholar ]. Among individuals with prediabetes, there is also greater chance of having comorbid dyslipidemia and atherosclerotic cardiovascular disease than those with normal glucose tolerance [ [6] Neves J.S. Newman C. Bostrom J.A. Buysschaert M. Newman J.D. Medina J.L. Goldberg I.J. Bergman M. Management of dyslipidemia and atherosclerotic cardiovascular risk in prediabetes. Diabetes Res. Clin. Pract. 2022; 190109980 Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar ], as well as higher risk of other complications including cancer, non-vascular and non-cancer death [ [10] Seshasai S.R. et al. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N. Engl. J. Med. 2011; 364: 829-841 Crossref PubMed Scopus (1962) Google Scholar ]. From The Emerging Risk Factors Collaboration, among the 820,900 participants from 97 prospective studies (58 % participants were from Europe, 6 % had diabetes at baseline, 123,205 deaths were recorded, median time to death as 13.6 years), men and women with diabetes had higher risk of all-cause, vascular, cancer, non-vascular and non-cancer mortality when compared to their non-diabetes counterparts [ [10] Seshasai S.R. et al. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N. Engl. J. Med. 2011; 364: 829-841 Crossref PubMed Scopus (1962) Google Scholar ]. Of note, the excess risk starts when fasting glucose levels are above 5.6 mmol per liter (100 mg per deciliter) suggesting the importance of early intervention at the prediabetes state [ [10] Seshasai S.R. et al. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N. Engl. J. Med. 2011; 364: 829-841 Crossref PubMed Scopus (1962) Google Scholar ]." @default.
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• W4382796757 date "2023-08-01" @default.
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• W4382796757 title "Management of people with prediabetes and the implementation of diabetes prevention programme" @default.
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• W4382796757 doi "https://doi.org/10.1016/j.pcd.2023.06.010" @default.
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