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- W4382797467 abstract "Striatal development is crucial for later motor, cognitive, and reward behavior, but age-related change in striatal physiology during the neonatal period remains understudied. An MRI-based measure of tissue iron deposition, T2*, is a non-invasive way to probe striatal physiology neonatally, linked to dopaminergic processing and cognition in children and adults. Striatal subregions have distinct functions that may come online at different time periods in early life. To identify if there are critical periods before or after birth, we measured if striatal iron accrued with gestational age at birth [range=34.57-41.85 weeks] or postnatal age at scan [range=5-64 days], using MRI to probe the T2* signal in N=83 neonates in three striatal subregions. We found iron increased with postnatal age in the pallidum and putamen but not the caudate. No significant relationship between iron and gestational age was observed. Using a subset of infants scanned at preschool age (N=26), we show distributions of iron shift between timepoints. In infants, the pallidum had the least iron of the three regions but had the most by preschool age. Together, this provides evidence of distinct change for striatal subregions, a possible differentiation between motor and cognitive systems, identifying a mechanism that may impact future trajectories.Neonatal striatal tissue iron can be measured using the T2* signal from rsfMRInT2* changed with postnatal age in the pallidum and putamen but not in the caudatenT2* did not change with gestational age in any of the three regionsPatterns of iron deposition (nT2*) among regions shift from infancy to preschool." @default.
- W4382797467 created "2023-07-02" @default.
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- W4382797467 date "2023-06-30" @default.
- W4382797467 modified "2023-10-14" @default.
- W4382797467 title "Gestational and postnatal age associations for striatal tissue iron deposition in early infancy" @default.
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- W4382797467 doi "https://doi.org/10.1101/2023.06.30.547249" @default.
- W4382797467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37425933" @default.
- W4382797467 hasPublicationYear "2023" @default.
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