Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382798082> ?p ?o ?g. }
- W4382798082 endingPage "112731" @default.
- W4382798082 startingPage "112731" @default.
- W4382798082 abstract "Energy-dissipating adipocytes have the potential to improve metabolic health. Here, we identify hypoxia-induced gene domain protein-1a (HIGD1A), a mitochondrial inner membrane protein, as a positive regulator of adipose browning. HIGD1A is induced in thermogenic fats by cold exposure. Peroxisome proliferator-activated receptor gamma (PPARγ) transactivates HIGD1A expression synergistically with peroxisome proliferators-activated receptor γ coactivator α (PGC1α). HIGD1A knockdown inhibits adipocyte browning, whereas HIGD1A upregulation promotes the browning process. Mechanistically, HIGD1A deficiency impairs mitochondrial respiration to increase reactive oxygen species (ROS) level. This increases NAD+ consumption for DNA damage repair and curtails the NAD+/NADH ratio, which inhibits sirtuin1 (SIRT1) activity, thereby compromising adipocyte browning. Conversely, overexpression of HIGD1A blunts the above process to promote adaptive thermogenesis. Furthermore, mice with HIGD1A knockdown in inguinal and brown fat have impaired thermogenesis and are prone to diet-induced obesity (DIO). Overexpression of HIGD1A favors adipose tissue browning, ultimately preventing DIO and metabolic disorders. Thus, the mitochondrial protein HIGD1A links SIRT1 activity to adipocyte browning by inhibiting ROS levels." @default.
- W4382798082 created "2023-07-02" @default.
- W4382798082 creator A5021972353 @default.
- W4382798082 creator A5050571063 @default.
- W4382798082 creator A5062442674 @default.
- W4382798082 creator A5064720996 @default.
- W4382798082 creator A5065212549 @default.
- W4382798082 date "2023-07-01" @default.
- W4382798082 modified "2023-10-18" @default.
- W4382798082 title "HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway" @default.
- W4382798082 cites W1930937854 @default.
- W4382798082 cites W1968650322 @default.
- W4382798082 cites W1969408132 @default.
- W4382798082 cites W1985775217 @default.
- W4382798082 cites W1989674299 @default.
- W4382798082 cites W1992326632 @default.
- W4382798082 cites W1996852459 @default.
- W4382798082 cites W2020304127 @default.
- W4382798082 cites W2032720768 @default.
- W4382798082 cites W2064662817 @default.
- W4382798082 cites W2077559325 @default.
- W4382798082 cites W2099540110 @default.
- W4382798082 cites W2112936536 @default.
- W4382798082 cites W2115928549 @default.
- W4382798082 cites W2141791765 @default.
- W4382798082 cites W2144822384 @default.
- W4382798082 cites W2167756858 @default.
- W4382798082 cites W2178337638 @default.
- W4382798082 cites W2273074294 @default.
- W4382798082 cites W2524399888 @default.
- W4382798082 cites W2540412673 @default.
- W4382798082 cites W2556127230 @default.
- W4382798082 cites W2589097869 @default.
- W4382798082 cites W2765883724 @default.
- W4382798082 cites W2883446651 @default.
- W4382798082 cites W2890465593 @default.
- W4382798082 cites W2899175196 @default.
- W4382798082 cites W2906120852 @default.
- W4382798082 cites W2944175483 @default.
- W4382798082 cites W2952892773 @default.
- W4382798082 cites W2969590229 @default.
- W4382798082 cites W2995734217 @default.
- W4382798082 cites W3021759774 @default.
- W4382798082 cites W3032931109 @default.
- W4382798082 cites W3100598681 @default.
- W4382798082 cites W3122663099 @default.
- W4382798082 cites W3153329305 @default.
- W4382798082 cites W3153807657 @default.
- W4382798082 cites W3159232901 @default.
- W4382798082 cites W3174033829 @default.
- W4382798082 cites W3208545238 @default.
- W4382798082 cites W3214150866 @default.
- W4382798082 cites W4200433606 @default.
- W4382798082 cites W4206993393 @default.
- W4382798082 cites W4212897153 @default.
- W4382798082 cites W4213297982 @default.
- W4382798082 cites W4224121299 @default.
- W4382798082 cites W4282959948 @default.
- W4382798082 cites W4283261402 @default.
- W4382798082 cites W4283789847 @default.
- W4382798082 cites W4287509805 @default.
- W4382798082 cites W4291021660 @default.
- W4382798082 cites W4306411847 @default.
- W4382798082 cites W4308891172 @default.
- W4382798082 cites W4378086048 @default.
- W4382798082 doi "https://doi.org/10.1016/j.celrep.2023.112731" @default.
- W4382798082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37393616" @default.
- W4382798082 hasPublicationYear "2023" @default.
- W4382798082 type Work @default.
- W4382798082 citedByCount "0" @default.
- W4382798082 crossrefType "journal-article" @default.
- W4382798082 hasAuthorship W4382798082A5021972353 @default.
- W4382798082 hasAuthorship W4382798082A5050571063 @default.
- W4382798082 hasAuthorship W4382798082A5062442674 @default.
- W4382798082 hasAuthorship W4382798082A5064720996 @default.
- W4382798082 hasAuthorship W4382798082A5065212549 @default.
- W4382798082 hasBestOaLocation W43827980821 @default.
- W4382798082 hasConcept C104317684 @default.
- W4382798082 hasConcept C126322002 @default.
- W4382798082 hasConcept C127078168 @default.
- W4382798082 hasConcept C127561419 @default.
- W4382798082 hasConcept C134018914 @default.
- W4382798082 hasConcept C151279926 @default.
- W4382798082 hasConcept C151955695 @default.
- W4382798082 hasConcept C170493617 @default.
- W4382798082 hasConcept C171089720 @default.
- W4382798082 hasConcept C173396325 @default.
- W4382798082 hasConcept C185592680 @default.
- W4382798082 hasConcept C2776175234 @default.
- W4382798082 hasConcept C2780642333 @default.
- W4382798082 hasConcept C28859421 @default.
- W4382798082 hasConcept C48349386 @default.
- W4382798082 hasConcept C53007507 @default.
- W4382798082 hasConcept C55493867 @default.
- W4382798082 hasConcept C71924100 @default.
- W4382798082 hasConcept C81979416 @default.
- W4382798082 hasConcept C86803240 @default.
- W4382798082 hasConcept C95444343 @default.