FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382799218> ?p ?o ?g. }

• W4382799218 endingPage "S149" @default.
• W4382799218 startingPage "S149" @default.
• W4382799218 abstract "Local and systemic treatments of colorectal liver metastases can improve survival and be curative. We aimed in our study to evaluate survival outcomes of liver treatment and to identify characteristics of the population which can benefit the most from this curative strategy. We conducted, in a Tunisian center, a retrospective study that included 52 patients treated for metastatic colorectal cancers with liver metastases. Patients received local treatment for liver lesions and primary tumors between 2012 and 2021. Survival outcomes: Overall Survival(OS) and disease free survival (DFS) and prognostic factors were determined using Kaplan Meier and Cox model respectively. Mean age was 53.4 years old [18-37] and 61.5% of our population were male. Primary tumor sites were the left colon in 57.7%, right colon in 23.1% and rectum in 19.2%. Synchronous liver metastases were registered in 75% of cases. Median number of liver metastases was 3 [1-15]. Four liver metastases or less were noted in 80.8% of cases. The largest diameter of liver metastasis was 4 cm or less in 51.9% of cases. Liver metastases were bilobar in 55.8% of patients (right lobe: 79%, left lobe: 21%). Liver lesions were classified as“resectable” and “potentially resectable” in 71% and 29 % of cases respectively. Perioperative chemotherapy (CT) was administered in 38.5%, postoperative CT in 25% and total preoperative CT in 36.5% of cases. Twelve patients (23%) received preoperative targeted therapies. All patients underwent liver surgery. Radiofrequency ablation and microwave ablation were performed in 4 and 2 patients respectively. Liver resection was complete (R0) in 73%, R1 in 24% and R2 in 4% of cases. Complete pathological response after liver surgery was registered in 4 cases. Hepatic sinusoidal obstruction syndrome (SOS) and chemotherapy associated steatohepatitis (CASH) were registered in 25% and 10% of cases respectively. Maintenance with 5-fluorouracil based CT after liver local treatment and peri/pre/post CT was administered to 11 patients. After liver treatment median DFS was 19 months [16.4 -21.56]. Patients who had not previously received adjuvant chemotherapy after resection of their primary tumor presented with better median DFS (34 months vs 20 months, p:0.054). Complete resection R0 was an independent factor improving DFS (p=0.01). Median OS was 58 months [33,8 -82,15]. Based on logistic regression, the factors correlating to a worse OS were age ≥ 55 years (p=0.041), bilobar metastases (p=0.001) and liver resection R1 or R2 (p < 0.001). Exposure to adjuvant chemotherapy may impact negatively DFS. Complete resection was an independent factor improving survival of patients with colorectal liver metastases." @default.
• W4382799218 created "2023-07-02" @default.
• W4382799218 creator A5009316957 @default.
• W4382799218 creator A5026561793 @default.
• W4382799218 creator A5040167291 @default.
• W4382799218 creator A5069176996 @default.
• W4382799218 creator A5071263027 @default.
• W4382799218 creator A5079356845 @default.
• W4382799218 creator A5059765266 @default.
• W4382799218 date "2023-06-01" @default.
• W4382799218 modified "2023-09-26" @default.
• W4382799218 title "P-388 Impact of the curative treatment of colorectal liver metastases" @default.
• W4382799218 doi "https://doi.org/10.1016/j.annonc.2023.04.444" @default.
• W4382799218 hasPublicationYear "2023" @default.
• W4382799218 type Work @default.
• W4382799218 citedByCount "0" @default.
• W4382799218 crossrefType "journal-article" @default.
• W4382799218 hasAuthorship W4382799218A5009316957 @default.
• W4382799218 hasAuthorship W4382799218A5026561793 @default.
• W4382799218 hasAuthorship W4382799218A5040167291 @default.
• W4382799218 hasAuthorship W4382799218A5059765266 @default.
• W4382799218 hasAuthorship W4382799218A5069176996 @default.
• W4382799218 hasAuthorship W4382799218A5071263027 @default.
• W4382799218 hasAuthorship W4382799218A5079356845 @default.
• W4382799218 hasBestOaLocation W43827992181 @default.
• W4382799218 hasConcept C121608353 @default.
• W4382799218 hasConcept C126322002 @default.
• W4382799218 hasConcept C141071460 @default.
• W4382799218 hasConcept C2776694085 @default.
• W4382799218 hasConcept C2777377203 @default.
• W4382799218 hasConcept C2778014663 @default.
• W4382799218 hasConcept C2778902805 @default.
• W4382799218 hasConcept C2779013556 @default.
• W4382799218 hasConcept C2781074409 @default.
• W4382799218 hasConcept C2908647359 @default.
• W4382799218 hasConcept C31174226 @default.
• W4382799218 hasConcept C526805850 @default.
• W4382799218 hasConcept C71924100 @default.
• W4382799218 hasConcept C90924648 @default.
• W4382799218 hasConcept C99454951 @default.
• W4382799218 hasConceptScore W4382799218C121608353 @default.
• W4382799218 hasConceptScore W4382799218C126322002 @default.
• W4382799218 hasConceptScore W4382799218C141071460 @default.
• W4382799218 hasConceptScore W4382799218C2776694085 @default.
• W4382799218 hasConceptScore W4382799218C2777377203 @default.
• W4382799218 hasConceptScore W4382799218C2778014663 @default.
• W4382799218 hasConceptScore W4382799218C2778902805 @default.
• W4382799218 hasConceptScore W4382799218C2779013556 @default.
• W4382799218 hasConceptScore W4382799218C2781074409 @default.
• W4382799218 hasConceptScore W4382799218C2908647359 @default.
• W4382799218 hasConceptScore W4382799218C31174226 @default.
• W4382799218 hasConceptScore W4382799218C526805850 @default.
• W4382799218 hasConceptScore W4382799218C71924100 @default.
• W4382799218 hasConceptScore W4382799218C90924648 @default.
• W4382799218 hasConceptScore W4382799218C99454951 @default.
• W4382799218 hasLocation W43827992181 @default.
• W4382799218 hasOpenAccess W4382799218 @default.
• W4382799218 hasPrimaryLocation W43827992181 @default.
• W4382799218 hasRelatedWork W1986167976 @default.
• W4382799218 hasRelatedWork W2327843085 @default.
• W4382799218 hasRelatedWork W2377431139 @default.
• W4382799218 hasRelatedWork W2415412146 @default.
• W4382799218 hasRelatedWork W2419399195 @default.
• W4382799218 hasRelatedWork W2607664512 @default.
• W4382799218 hasRelatedWork W3025059926 @default.
• W4382799218 hasRelatedWork W3097995588 @default.
• W4382799218 hasRelatedWork W3118425896 @default.
• W4382799218 hasRelatedWork W2743423219 @default.
• W4382799218 hasVolume "34" @default.
• W4382799218 isParatext "false" @default.
• W4382799218 isRetracted "false" @default.
• W4382799218 workType "article" @default.