Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382799223> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4382799223 endingPage "S126" @default.
- W4382799223 startingPage "S126" @default.
- W4382799223 abstract "While many studies have been undertaken to prove the efficacy of nab-paclitaxel with gemcitabine and FOLFIRINOX as first line treatment options of advanced pancreatic cancer, there is limited data available exploring options for further treatment lines. In a disease where only 15-20% of tumours are resectable at diagnosis there is a huge lack of evidence for further lines of chemotherapy. As a single centre In WA, we have previously reported our experience of twenty six patients who received first-line treatment with gemcitabine plus nab-paclitaxel, second-line FOLFIRONOX and third-line retreatment with gemcitabine plus nab-paclitaxel between January 2013 and December 2018. This retrospective study is an update on the previously reported data. This was a retrospective analysis using an electronic database of patients with metastatic or locally advanced pancreatic adenocarcinoma who received first-line and third-line treatment with gemcitabine and nab-paclitaxel between January 2013 and January 2023 in a single centre in Western Australia. Patients had an ECOG performance status of 2 or less. Overall survival (OS) was estimated by the Kaplan-Meier method. There were 50 patients identified in our analysis. The median age of patients was 63 (range, 38 – 82). 40% of the studied patients had metastatic disease at diagnosis. 48% were female. Median OS from diagnosis for the metastatic group was 44.0 months (95% CI, 21.0 – 65.0) compared to the locally advanced group 66.0 months (95% CI, 36.0 – 74.0). This data suggests a possible benefit from the retreatment of advanced pancreatic adenocarcinoma with gemcitabine and nab-paclitaxel. Formal phase three studies are needed to further support our hypothesis." @default.
- W4382799223 created "2023-07-02" @default.
- W4382799223 creator A5006817293 @default.
- W4382799223 creator A5012899043 @default.
- W4382799223 creator A5022112281 @default.
- W4382799223 creator A5035394592 @default.
- W4382799223 creator A5037391423 @default.
- W4382799223 creator A5037999038 @default.
- W4382799223 creator A5052709676 @default.
- W4382799223 creator A5058655394 @default.
- W4382799223 creator A5070006103 @default.
- W4382799223 creator A5080018254 @default.
- W4382799223 creator A5083205649 @default.
- W4382799223 creator A5090294760 @default.
- W4382799223 creator A5092376774 @default.
- W4382799223 date "2023-06-01" @default.
- W4382799223 modified "2023-09-25" @default.
- W4382799223 title "P-316 A retrospective study of gemcitabine with nab-paclitaxel as third-line retreatment in advanced pancreatic adenocarcinoma" @default.
- W4382799223 doi "https://doi.org/10.1016/j.annonc.2023.04.372" @default.
- W4382799223 hasPublicationYear "2023" @default.
- W4382799223 type Work @default.
- W4382799223 citedByCount "0" @default.
- W4382799223 crossrefType "journal-article" @default.
- W4382799223 hasAuthorship W4382799223A5006817293 @default.
- W4382799223 hasAuthorship W4382799223A5012899043 @default.
- W4382799223 hasAuthorship W4382799223A5022112281 @default.
- W4382799223 hasAuthorship W4382799223A5035394592 @default.
- W4382799223 hasAuthorship W4382799223A5037391423 @default.
- W4382799223 hasAuthorship W4382799223A5037999038 @default.
- W4382799223 hasAuthorship W4382799223A5052709676 @default.
- W4382799223 hasAuthorship W4382799223A5058655394 @default.
- W4382799223 hasAuthorship W4382799223A5070006103 @default.
- W4382799223 hasAuthorship W4382799223A5080018254 @default.
- W4382799223 hasAuthorship W4382799223A5083205649 @default.
- W4382799223 hasAuthorship W4382799223A5090294760 @default.
- W4382799223 hasAuthorship W4382799223A5092376774 @default.
- W4382799223 hasBestOaLocation W43827992231 @default.
- W4382799223 hasConcept C121608353 @default.
- W4382799223 hasConcept C126322002 @default.
- W4382799223 hasConcept C141071460 @default.
- W4382799223 hasConcept C143998085 @default.
- W4382799223 hasConcept C167135981 @default.
- W4382799223 hasConcept C2776694085 @default.
- W4382799223 hasConcept C2777148230 @default.
- W4382799223 hasConcept C2777292972 @default.
- W4382799223 hasConcept C2780210213 @default.
- W4382799223 hasConcept C2780258809 @default.
- W4382799223 hasConcept C2780259306 @default.
- W4382799223 hasConcept C2781182431 @default.
- W4382799223 hasConcept C526805850 @default.
- W4382799223 hasConcept C71924100 @default.
- W4382799223 hasConceptScore W4382799223C121608353 @default.
- W4382799223 hasConceptScore W4382799223C126322002 @default.
- W4382799223 hasConceptScore W4382799223C141071460 @default.
- W4382799223 hasConceptScore W4382799223C143998085 @default.
- W4382799223 hasConceptScore W4382799223C167135981 @default.
- W4382799223 hasConceptScore W4382799223C2776694085 @default.
- W4382799223 hasConceptScore W4382799223C2777148230 @default.
- W4382799223 hasConceptScore W4382799223C2777292972 @default.
- W4382799223 hasConceptScore W4382799223C2780210213 @default.
- W4382799223 hasConceptScore W4382799223C2780258809 @default.
- W4382799223 hasConceptScore W4382799223C2780259306 @default.
- W4382799223 hasConceptScore W4382799223C2781182431 @default.
- W4382799223 hasConceptScore W4382799223C526805850 @default.
- W4382799223 hasConceptScore W4382799223C71924100 @default.
- W4382799223 hasLocation W43827992231 @default.
- W4382799223 hasOpenAccess W4382799223 @default.
- W4382799223 hasPrimaryLocation W43827992231 @default.
- W4382799223 hasRelatedWork W2071322563 @default.
- W4382799223 hasRelatedWork W2165480504 @default.
- W4382799223 hasRelatedWork W2599910524 @default.
- W4382799223 hasRelatedWork W2911341297 @default.
- W4382799223 hasRelatedWork W2947142514 @default.
- W4382799223 hasRelatedWork W3008650849 @default.
- W4382799223 hasRelatedWork W3046481916 @default.
- W4382799223 hasRelatedWork W3143800975 @default.
- W4382799223 hasRelatedWork W3196960728 @default.
- W4382799223 hasRelatedWork W4236716409 @default.
- W4382799223 hasVolume "34" @default.
- W4382799223 isParatext "false" @default.
- W4382799223 isRetracted "false" @default.
- W4382799223 workType "article" @default.