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- W4382806810 abstract "KRAS mutation status is known to have prognostic value in patients with colorectal cancer. However, prognostic value of KRAS mutation is not well established in patients with rectal cancer alone. This study aimed to evaluate survival of overall rectal cancer patients according to KRAS mutation status.KRAS mutation status is known to have prognostic value in patients with colorectal cancer. However, prognostic value of KRAS mutation is not well established in patients with rectal cancer alone. This study aimed to evaluate survival of overall rectal cancer patients according to KRAS mutation status. The Korean Center of Cancer Registry performed the Collaborative Stage Data Survey between 2010 and 2015 to establish collaborative stage data (CSD) of cancers of stomach, colon, rectum, rectosigmoid junction, and breast. Information on patients with rectal cancer was extracted from the CSD for analysis. Variables including age, sex, diagnosis date, American Joint Committee on Cancer (AJCC) staging system scores were analyzed. Cox proportional hazard regression analyses were used to evaluate prognostic factors and survival analysis was performed using the Kaplan–Meier method. A total of 1549 rectal cancer patients with KRAS test result were identified, among them 990 (63.9%) had wild type KRAS and 559 (36.1%) had mutated KRAS. Multivariate analysis showed that mutated type KRAS was an independent risk factor for survival (Hazard ratio (HR): 1.267, 95% confidence interval (CI): 1.052-1.526). Overall survival of wild type KRAS was significantly higher than that of mutated type KRAS (p=0.007). When stratified according to AJCC7 stages, survival curves of wild type KRAS showed higher survival to that of mutated type KRAS in AJCC7 stage II-III (p=0.023). Mutated KRAS status had significantly worse prognostic value in patients with rectal cancer, especially in stage II-III." @default.
- W4382806810 created "2023-07-02" @default.
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- W4382806810 date "2023-06-01" @default.
- W4382806810 modified "2023-09-23" @default.
- W4382806810 title "P-4 KRAS mutation and survival of rectal cancer in Korea between 2010 and 2015: Analysis of the Collaborative Stage Data of Korean Central Cancer Registry" @default.
- W4382806810 doi "https://doi.org/10.1016/j.annonc.2023.04.060" @default.
- W4382806810 hasPublicationYear "2023" @default.
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