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- W4382806959 abstract "Little attention has been paid to the prognostic value of non-hormonal symptoms in patients with NENs. This study aims to assess the relationship between patient- reported symptoms that are not attributable to excessive hormone production and outcomes in patients with NENs. This is a retrospective, registry-based study, derived from administrative databases of the province of Alberta, Canada. Univariable and multivariable Cox’s Proportional Hazard Regression analyses were used to examine impacts of overall symptoms (i.e., pooled number of the nine symptoms) as well as individual Edmonton Symptom Assessment Score (ESAS) measurements on overall survival (OS). A total of 802 patients were considered eligible and they were included into the current study. Within multivariable models, the following elements were individually associated with worse OS: pain, HR: 1.208 (95% CI: 1.132-1.290); tiredness, HR: 1.113 (95% CI: 1.043-1.187); drowsiness, HR: 1.169 (95% CI: 1.098-1.244); nausea, HR: 1.218 (95% CI: 1.132-1.310); lack of appetite, HR: 1.178 (95% CI: 1.113-1.247); shortness of breath, HR: 1.089 (95% CI: 1.019-1.165); and wellbeing, HR (1.158 (95% CI: 1.082-1.240). Additionally, mean score, as well as overall score were individually associated with worse OS. For mean score, HR was 1.281 (95% CI: 1.167-1.406); and for overall score, HR was 1.028 (1.017–1.039). This study highlights the prognostic value of patient-reported symptoms for patients with NENs and calls for more attention to routinely collected symptom burden data." @default.
- W4382806959 created "2023-07-02" @default.
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- W4382806959 date "2023-06-01" @default.
- W4382806959 modified "2023-10-07" @default.
- W4382806959 title "P-17 Impacts of patient-reported non-hormonal symptoms on outcomes of patients with neuroendocrine neoplasms (NENs)" @default.
- W4382806959 doi "https://doi.org/10.1016/j.annonc.2023.04.073" @default.
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