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- W4382808704 abstract "Skin-cancer melanoma caused 57k death in 2020. Some of the available therapies are: topical application of a gel loaded with an anti-skin cancer drug and intravenous injection of immune cytokines; however, both the approaches have drawbacks such as inefficient internalization of the drug in cancer cells and a short half-life with severe side effects, respectively. Interestingly, we observed for the first time that a subcutaneously implanted hydrogel designed and synthesized by coordinating NSAIDs and 5-AP with Zn(II) can effectively combat melanoma cell (B16-F10)-induced tumors in C57BL/6 mice. Both in vitro and in vivo results show that it can effectively reduce PGE2 expression, consequently upregulating IFN-γ and IL-12 that eventually engage M1-macrophages for activating T cells (CD8+), triggering apoptosis. This unique all-in-one self-drug-delivery approach, wherein the hydrogel implant is made from the drug molecules itself providing both chemotherapy and immunotherapy in combating deadly melanoma, highlights the supramolecular chemistry-based bottom-up approach in cancer therapy." @default.
- W4382808704 created "2023-07-02" @default.
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- W4382808704 date "2023-01-01" @default.
- W4382808704 modified "2023-10-16" @default.
- W4382808704 title "An injectable supramolecular hydrogel as self-drug-delivery system for local chemoimmunotherapy against melanoma" @default.
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- W4382808704 doi "https://doi.org/10.1039/d3bm00758h" @default.
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