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• W4382811203 abstract "Colorectal cancer (CRC) is the third most common cancer worldwide. Although around 60% of CRC patients are > 70 years of age, there are few trials specific for that age group. Older patients may have frailty that could influence oncological treatments tolerability. Evidence supports multidisciplinary team management and use of geriatric assessment (GA), or validated screening tools to select patients who need full GA, to identify vulnerable patients. However, these strategies are not always easily performed in real-world practice. We aimed to identify risk factors within our older CRC population that might predict toxicity and hospital admissions related to age and systemic anticancer treatment. Using an electronic health record we identified a series of 200 consecutively treated CRC patients who started oncological treatment from November 2019 to February 2022. Using a cut-off of 70 years, we compared older to younger patients. We collected baseline data regarding clinical, laboratory, molecular and pathological features and treatment administered including about toxicity grading and hospital admissions during the first cycle of treatment. Toxicities were evaluated according to Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0. Analysis were conducted using Xlstat statistical software. In the 200 patient series, median age was 67.5 years (range 20 - 91), 84 patients (42%) were > 70 years, while 116 (58%) were 70-year subgroup, p 0.002 and p 0.015). Patients who had a dose reduction or received combination chemotherapy versus mono-chemotherapy were not more likely to be admitted to hospital or experience toxicities (all p > 0.05). In multivariate analysis accounting for age, chemotherapy regimen (mono- versus combination chemotherapy) and dose reduction, grade 3 or 4 toxicities and hospital admissions remained significantly more common in younger patients (respectively, OR 4.401, 95% CI 1.364 – 14.201; p 0.013 and OR 3.420, 95% CI 1.311-8.922; p 0.012). Older age was not associated with an increased risk of severe treatment-related toxicity. However, elderly patients received less intense chemotherapy regimen with a higher proportion of dose reduction than younger patients. These data suggests that a tailor-made approach is safe in elderly CRC patients. Further prospective studies are needed to increase the evidence base in the treatment of elderly CRC patients and to avoid undertreatment." @default.
• W4382811203 created "2023-07-02" @default.
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• W4382811203 date "2023-06-01" @default.
• W4382811203 modified "2023-09-23" @default.
• W4382811203 title "P-398 Early chemo- and immuno-related toxicities in previously untreated colorectal cancer patients according to age: A retrospective single-centre study" @default.
• W4382811203 doi "https://doi.org/10.1016/j.annonc.2023.04.454" @default.
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