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- W4382811541 abstract "Circulating tumor DNA (ctDNA) has emerged as a tool for risk stratification in patients with early stage CRC and to monitor the response to IO in immunogenic cancers like NSCLC. We evaluated the correlation of serial Signatera™ ctDNA levels with clinical outcome in patients with MSI-H/dMMR CRC treated with IO therapy at West Cancer Center and Research Institute (WCCRI). Patients with metastatic or locally advanced MSI-H/dMMR CRC who were treated with IO therapy as first- or second-line therapy. Serial ctDNA levels were prospectively obtained to monitor treatment response in correlation with imaging findings and clinical outcome. Twelve patients with MSI-H/dMMR CRC (8 female, age 38-90, median age 68.5, metastatic: 11, locally advanced: 1) received IO therapy as first (6 pts)- or second-line (6 pts) therapy (Pembro: 6, Nivo/Ipi: 5, Atezo:1). All pts had detectable ctDNA levels with initial Mean Tumor Molecules/mL ranging from 5705 to 0.26. IO therapy led to conversion of ctDNA to negative in 11 pts with time to ctDNA conversion ranging from 2 to 6 months. 10 pts with ctDNA conversion continued to have negative ctDNA results after a median follow-up of 12.5 mos (range 4-36 mos) while CT imaging showed persistent indeterminate residual findings in 5 of these pts. 1 pt showed increased ctDNA on IO therapy with an emerging adrenal met. CtDNA levels correlate well with clinical response on IO therapy in patients with MSI-H/dMMR CRC. CtDNA conversions happen rapidly and are mostly sustained after IO therapy even in patients with indeterminate findings on conventional imaging. Serial ctDNA testing can help guide IO treatment in highly immunogenic CRC." @default.
- W4382811541 created "2023-07-02" @default.
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- W4382811541 date "2023-06-01" @default.
- W4382811541 modified "2023-09-27" @default.
- W4382811541 title "P-307 Serial ctDNA monitoring during immunotherapy (IO) in patients (pts) with MSI-H/dMMR advanced colorectal cancer (CRC)" @default.
- W4382811541 doi "https://doi.org/10.1016/j.annonc.2023.04.363" @default.
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