FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382874310> ?p ?o ?g. }

• W4382874310 endingPage "S26" @default.
• W4382874310 startingPage "S25" @default.
• W4382874310 abstract "Abstract Introduction High-dose ascorbic acid (HDAA) plays an important role in oxygen radical elimination which is a major cause of pathophysiological derangement in burn patients. However, there was limited explicit data on the clinical effect of HDAA in major burn patients. The purpose of this study was to identify the benefit and risks of HDAA in major burn patients. Methods MEDLINE, EMBASE, and Cochrane database searches were conducted. An additional search of relevant primary literature and review articles was performed. All the studies related to HDAA and burn were included in the analysis. HDAA group was defined by receiving ascorbic acid 66 mg/kg/day in the first 24 hours. The primary outcome was the 24-hour fluid requirement. The secondary outcomes were in-hospital mortality, 24-hour urine output, ventilator day, hospital length of stay, and in-hospital complications. Pooled incidences and 95% confidence interval (CI) were calculated and summarized using a random effect model on Stata/MP 16.1. Results Of 875 studies, 7 articles (293 patients) were included in this meta-analysis. HDAA significantly reduced 24-hour fluid requirement compared with usual care (no HDAA) (SMD -0.75 ml/kg per TBSA, 95% CI [-1.38 to -0.12]). HDAA group showed a decrease in 24-hour urine output (SMD, 0.65; 95% CI, 0.41 to 0.89). However, it did not demonstrate significant increase in acute kidney injury (RR 1.37, 95% CI [0.60 to 3.13]) and the need for renal replacement therapy (RR 1.31, 95% CI [0.50 to 3.44]). In terms of in-hospital complications, there was no significant difference in abdominal compartment syndrome (RR 0.22, 95% CI [0.08 to 0.89]) and pneumonia or acute respiratory distress syndrome (RR 1.03, 95% CI [0.70 to 1.51]). Though there was a trend to decrease mortality in the HDAA group, there was no statistical difference in mortality (RR 1.27, 95% CI [0.85 to 1.91]). HDAA group had a comparable hospital length of stay (SMD 0.1, 95% CI [-0.44 to 0.63]) and ventilator day (SMD 0.03, 95% CI [-0.64 to 0.70]). Conclusions High-dose ascorbic acid had a clinical benefit in the significant reduction of 24-hour fluid requirement without increasing the risk for acute kidney injury or the need for renal replacement therapy. Though it did not demonstrate a significant improvement in mortality or length of stay, there were no significant reported complications from high-dose ascorbic acid. A multicenter randomized controlled trial is warranted. Applicability of Research to Practice The potential benefit of HDAA in major burn" @default.
• W4382874310 created "2023-07-02" @default.
• W4382874310 creator A5013286259 @default.
• W4382874310 creator A5013520355 @default.
• W4382874310 creator A5092379582 @default.
• W4382874310 date "2023-05-01" @default.
• W4382874310 modified "2023-09-25" @default.
• W4382874310 title "57 Effect of High-Dose Ascorbic Acid in Major Burn Patients: A Systematic Review and Meta-Analysis" @default.
• W4382874310 doi "https://doi.org/10.1093/jbcr/irad045.031" @default.
• W4382874310 hasPublicationYear "2023" @default.
• W4382874310 type Work @default.
• W4382874310 citedByCount "0" @default.
• W4382874310 crossrefType "journal-article" @default.
• W4382874310 hasAuthorship W4382874310A5013286259 @default.
• W4382874310 hasAuthorship W4382874310A5013520355 @default.
• W4382874310 hasAuthorship W4382874310A5092379582 @default.
• W4382874310 hasBestOaLocation W43828743101 @default.
• W4382874310 hasConcept C126322002 @default.
• W4382874310 hasConcept C185592680 @default.
• W4382874310 hasConcept C2779541074 @default.
• W4382874310 hasConcept C2780026642 @default.
• W4382874310 hasConcept C2780472472 @default.
• W4382874310 hasConcept C2986274086 @default.
• W4382874310 hasConcept C31903555 @default.
• W4382874310 hasConcept C44249647 @default.
• W4382874310 hasConcept C71924100 @default.
• W4382874310 hasConcept C82789193 @default.
• W4382874310 hasConcept C95190672 @default.
• W4382874310 hasConceptScore W4382874310C126322002 @default.
• W4382874310 hasConceptScore W4382874310C185592680 @default.
• W4382874310 hasConceptScore W4382874310C2779541074 @default.
• W4382874310 hasConceptScore W4382874310C2780026642 @default.
• W4382874310 hasConceptScore W4382874310C2780472472 @default.
• W4382874310 hasConceptScore W4382874310C2986274086 @default.
• W4382874310 hasConceptScore W4382874310C31903555 @default.
• W4382874310 hasConceptScore W4382874310C44249647 @default.
• W4382874310 hasConceptScore W4382874310C71924100 @default.
• W4382874310 hasConceptScore W4382874310C82789193 @default.
• W4382874310 hasConceptScore W4382874310C95190672 @default.
• W4382874310 hasIssue "Supplement_2" @default.
• W4382874310 hasLocation W43828743101 @default.
• W4382874310 hasOpenAccess W4382874310 @default.
• W4382874310 hasPrimaryLocation W43828743101 @default.
• W4382874310 hasRelatedWork W1885119863 @default.
• W4382874310 hasRelatedWork W2171938400 @default.
• W4382874310 hasRelatedWork W2318187771 @default.
• W4382874310 hasRelatedWork W2598584487 @default.
• W4382874310 hasRelatedWork W2626084264 @default.
• W4382874310 hasRelatedWork W3007491672 @default.
• W4382874310 hasRelatedWork W4200280324 @default.
• W4382874310 hasRelatedWork W4223618967 @default.
• W4382874310 hasRelatedWork W4233251381 @default.
• W4382874310 hasRelatedWork W4379197432 @default.
• W4382874310 hasVolume "44" @default.
• W4382874310 isParatext "false" @default.
• W4382874310 isRetracted "false" @default.
• W4382874310 workType "article" @default.