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- W4382888775 abstract "We aimed to investigate eye damage caused by ocular iontophoresis (IP) based on an in vitro eye irritation test using a reconstructed human corneal cell. In this study, the LabCyte CORNEA-MODEL was selected as the reconstructed corneal cell. The test procedure was performed according to Test Guideline No.492 of the Organisation for Economic Co-operation and Development, which was partially revised for the IP. From the relationship between the cell viability of the cornea model and the electric field intensity [current density (mA/cm2) × application time (min)] of the IP, we predicted that the intensity values of 465 mA/cm2 × min and 930 mA/cm2 × min caused reversible eye irritation and irreversible eye damage, respectively. However, further studies are required to improve the accuracy and reproducibility of the prediction. This report provides essential knowledge on the clinical safety of ocular IP." @default.
- W4382888775 created "2023-07-03" @default.
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- W4382888775 date "2023-07-01" @default.
- W4382888775 modified "2023-10-14" @default.
- W4382888775 title "Predicting the Safety of Ocular Iontophoresis Using Reconstructed Human Corneal Epithelial Cells" @default.
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- W4382888775 doi "https://doi.org/10.1248/bpb.b23-00096" @default.
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