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- W4382893172 abstract "Apurinic/apyrimidinic endonuclease 1 (APE1), also known as redox factor-1 (Ref-1), is a multifunctional protein which is widely existing in living organisms. It can specifically recognize and cleave the DNA in apurinic/apyrimidinic (AP) site in the base excision repair (BER) pathway, as well as regulate the expression of genes to activate some transcription factors. The abnormal ex-pression and disruptions in the biological functions of APE1 are linked to a number of diseases, including inflammation, immunodeficiency, and cancer. Hence, it is extremely desired to monitor the activity of APE1, acquiring a thorough understanding of the healing process of damaged DNA and making clinical diagnoses. Thanks to the advent of DNA nanotechnology, some nanodevices are used to image the activity of APE1 with great sensitivity and simplicity. In this review, we will summarize DNA nanotechnology-empowered fluorescence imaging in the past years for APE1 activity according to the types of DNA probe, which are classified into linear DNA probes, composite DNA nanomaterials and three-dimensional (3D) DNA nanostructures. We also highlight the future research directions in the field of APE1 activity imaging." @default.
- W4382893172 created "2023-07-03" @default.
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- W4382893172 date "2023-06-30" @default.
- W4382893172 modified "2023-10-16" @default.
- W4382893172 title "DNA Nanotechnology-Empowered Fluorescence Imaging of APE1 Activity" @default.
- W4382893172 doi "https://doi.org/10.20944/preprints202306.2208.v1" @default.
- W4382893172 hasPublicationYear "2023" @default.
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