Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382893287> ?p ?o ?g. }
- W4382893287 endingPage "1379" @default.
- W4382893287 startingPage "1371" @default.
- W4382893287 abstract "Amino acids are fundamental units of molecular components that are essential for sustaining life; however, their metabolism is closely interconnected to the control systems of cell function. Tryptophan (Trp) is an essential amino acid catabolized by complex metabolic pathways. Several of the resulting Trp metabolites are bioactive and play central roles in physiology and pathophysiology. Additionally, various physiological functions of Trp metabolites are mutually regulated by the gut microbiota and intestine to coordinately maintain intestinal homeostasis and symbiosis under steady state conditions and during the immune response to pathogens and xenotoxins. Cancer and inflammatory diseases are associated with dysbiosis- and host-related aberrant Trp metabolism and inactivation of the aryl hydrocarbon receptor (AHR), which is a receptor of several Trp metabolites. In this review, we focus on the mechanisms through which Trp metabolism converges to AHR activation for the modulation of immune function and restoration of tissue homeostasis and how these processes can be targeted using therapeutic approaches for cancer and inflammatory and autoimmune diseases." @default.
- W4382893287 created "2023-07-03" @default.
- W4382893287 creator A5054866052 @default.
- W4382893287 creator A5061511587 @default.
- W4382893287 date "2023-07-03" @default.
- W4382893287 modified "2023-10-16" @default.
- W4382893287 title "Immune regulation through tryptophan metabolism" @default.
- W4382893287 cites W1506816544 @default.
- W4382893287 cites W1878777740 @default.
- W4382893287 cites W1966226308 @default.
- W4382893287 cites W1968797543 @default.
- W4382893287 cites W1970864665 @default.
- W4382893287 cites W1981177186 @default.
- W4382893287 cites W1984584304 @default.
- W4382893287 cites W1987772726 @default.
- W4382893287 cites W1991392411 @default.
- W4382893287 cites W2004522121 @default.
- W4382893287 cites W2007316487 @default.
- W4382893287 cites W2007489575 @default.
- W4382893287 cites W2008343182 @default.
- W4382893287 cites W2010343273 @default.
- W4382893287 cites W2010378562 @default.
- W4382893287 cites W2028370526 @default.
- W4382893287 cites W2037259928 @default.
- W4382893287 cites W2037920661 @default.
- W4382893287 cites W2040114517 @default.
- W4382893287 cites W2040177546 @default.
- W4382893287 cites W2044104392 @default.
- W4382893287 cites W2044216294 @default.
- W4382893287 cites W2052006922 @default.
- W4382893287 cites W2053485564 @default.
- W4382893287 cites W2054310494 @default.
- W4382893287 cites W2068162195 @default.
- W4382893287 cites W2068912461 @default.
- W4382893287 cites W2069677284 @default.
- W4382893287 cites W2088058388 @default.
- W4382893287 cites W2089954661 @default.
- W4382893287 cites W2090871342 @default.
- W4382893287 cites W2110957620 @default.
- W4382893287 cites W2117395989 @default.
- W4382893287 cites W2122285073 @default.
- W4382893287 cites W2123812720 @default.
- W4382893287 cites W2134892089 @default.
- W4382893287 cites W2146934919 @default.
- W4382893287 cites W2148196931 @default.
- W4382893287 cites W2163590547 @default.
- W4382893287 cites W2170758122 @default.
- W4382893287 cites W2202295242 @default.
- W4382893287 cites W2273004055 @default.
- W4382893287 cites W2345604850 @default.
- W4382893287 cites W2346752870 @default.
- W4382893287 cites W2579019451 @default.
- W4382893287 cites W2583483044 @default.
- W4382893287 cites W2588356762 @default.
- W4382893287 cites W2597506739 @default.
- W4382893287 cites W2730436383 @default.
- W4382893287 cites W2741302852 @default.
- W4382893287 cites W2756156305 @default.
- W4382893287 cites W2761575992 @default.
- W4382893287 cites W2785540442 @default.
- W4382893287 cites W2790230144 @default.
- W4382893287 cites W2790897054 @default.
- W4382893287 cites W2800526280 @default.
- W4382893287 cites W2803938554 @default.
- W4382893287 cites W2810291120 @default.
- W4382893287 cites W2883853179 @default.
- W4382893287 cites W2887221348 @default.
- W4382893287 cites W2890999381 @default.
- W4382893287 cites W2911746882 @default.
- W4382893287 cites W2930154557 @default.
- W4382893287 cites W2936414047 @default.
- W4382893287 cites W2949375297 @default.
- W4382893287 cites W2952771677 @default.
- W4382893287 cites W2955181150 @default.
- W4382893287 cites W2963927525 @default.
- W4382893287 cites W2981900400 @default.
- W4382893287 cites W2993480792 @default.
- W4382893287 cites W2995136651 @default.
- W4382893287 cites W3000043134 @default.
- W4382893287 cites W3001787418 @default.
- W4382893287 cites W3005054591 @default.
- W4382893287 cites W3013413712 @default.
- W4382893287 cites W3030163031 @default.
- W4382893287 cites W3048476288 @default.
- W4382893287 cites W3049896770 @default.
- W4382893287 cites W3094376062 @default.
- W4382893287 cites W3107228712 @default.
- W4382893287 cites W3113999242 @default.
- W4382893287 cites W3119561596 @default.
- W4382893287 cites W3126902084 @default.
- W4382893287 cites W3129126066 @default.
- W4382893287 cites W3129279916 @default.
- W4382893287 cites W3129598503 @default.
- W4382893287 cites W3133721962 @default.
- W4382893287 cites W3137177918 @default.
- W4382893287 cites W3138719602 @default.
- W4382893287 cites W3169986140 @default.
- W4382893287 cites W3176332101 @default.