FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382893802> ?p ?o ?g. }

• W4382893802 abstract "Identifying factors that influence the stability of DNA methylation measurements across biological replicates is of critical importance in basic and clinical research. Using a within-person between-group experimental design (n = 31, number of observations = 192), we report the stability of biological replicates over a variety of unique temporal scenarios, both in the absence and presence of acute psychosocial stress, and between individuals who have experienced early life adversity (ELA) and non-exposed individuals. We found that varying time intervals, acute stress, and ELA exposure influenced the stability of repeated DNA methylation measurements. In the absence of acute stress, probes were less stable as time passed; however, stress exerted a stabilizing influence on probes over longer time intervals. Compared to non-exposed individuals, ELA-exposed individuals had significantly lower probe stability immediately following acute stress. Additionally, we found that across all scenarios, probes used in most epigenetic-based algorithms for estimating epigenetic age or immune cell proportions had average or below-average stability, except for the Principal Component and DunedinPACE epigenetic ageing clocks, which were enriched for more stable probes. Finally, using highly stable probes in the absence of stress, we identified multiple probes that were hypomethylated in the presence of acute stress, regardless of ELA status. Two hypomethylated probes are located near the transcription start site of the glutathione-disulfide reductase gene (GSR), which has previously been shown to be an integral part of the stress response to environmental toxins. We discuss implications for future studies concerning the reliability and reproducibility of DNA methylation measurements.Abbreviations: DNAm – DNA methylation, CpG − 5’-cytosine-phosphate-guanine-3,’ ICC – Interclass correlation coefficient, ELA – Early-life adversity, PBMCs – Peripheral blood mononuclear cells, mQTL – Methylation quantitative trait loci, TSS – Transcription start site, GSR – Glutathione-disulfide reductase gene, TSST – Trier social stress test, PC – Principal component." @default.
• W4382893802 created "2023-07-03" @default.
• W4382893802 creator A5031758996 @default.
• W4382893802 creator A5037350829 @default.
• W4382893802 creator A5045323045 @default.
• W4382893802 creator A5047495439 @default.
• W4382893802 creator A5059900250 @default.
• W4382893802 creator A5061108604 @default.
• W4382893802 creator A5083460285 @default.
• W4382893802 creator A5090244949 @default.
• W4382893802 date "2023-07-02" @default.
• W4382893802 modified "2023-10-18" @default.
• W4382893802 title "Biological stability of DNA methylation measurements over varying intervals of time and in the presence of acute stress" @default.
• W4382893802 cites W1527534059 @default.
• W4382893802 cites W1592968073 @default.
• W4382893802 cites W1964081088 @default.
• W4382893802 cites W1974047233 @default.
• W4382893802 cites W1989342631 @default.
• W4382893802 cites W1994025158 @default.
• W4382893802 cites W2004078197 @default.
• W4382893802 cites W2038241370 @default.
• W4382893802 cites W2041597075 @default.
• W4382893802 cites W2056040742 @default.
• W4382893802 cites W2082022902 @default.
• W4382893802 cites W2101870168 @default.
• W4382893802 cites W2121091193 @default.
• W4382893802 cites W2132152083 @default.
• W4382893802 cites W2138207763 @default.
• W4382893802 cites W2139077902 @default.
• W4382893802 cites W2141884293 @default.
• W4382893802 cites W2169456326 @default.
• W4382893802 cites W2327037637 @default.
• W4382893802 cites W2489743084 @default.
• W4382893802 cites W2529024004 @default.
• W4382893802 cites W2553272317 @default.
• W4382893802 cites W2605316934 @default.
• W4382893802 cites W2609789137 @default.
• W4382893802 cites W2734488892 @default.
• W4382893802 cites W2745699865 @default.
• W4382893802 cites W2793232416 @default.
• W4382893802 cites W2794333713 @default.
• W4382893802 cites W2805049578 @default.
• W4382893802 cites W2949100461 @default.
• W4382893802 cites W2949437525 @default.
• W4382893802 cites W2952176770 @default.
• W4382893802 cites W2961404751 @default.
• W4382893802 cites W3002407307 @default.
• W4382893802 cites W3002874468 @default.
• W4382893802 cites W3011777860 @default.
• W4382893802 cites W3014935908 @default.
• W4382893802 cites W3047112402 @default.
• W4382893802 cites W3099862724 @default.
• W4382893802 cites W4205380741 @default.
• W4382893802 cites W4220700446 @default.
• W4382893802 cites W4285492214 @default.
• W4382893802 cites W4309667218 @default.
• W4382893802 doi "https://doi.org/10.1080/15592294.2023.2230686" @default.
• W4382893802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37393564" @default.
• W4382893802 hasPublicationYear "2023" @default.
• W4382893802 type Work @default.
• W4382893802 citedByCount "0" @default.
• W4382893802 crossrefType "journal-article" @default.
• W4382893802 hasAuthorship W4382893802A5031758996 @default.
• W4382893802 hasAuthorship W4382893802A5037350829 @default.
• W4382893802 hasAuthorship W4382893802A5045323045 @default.
• W4382893802 hasAuthorship W4382893802A5047495439 @default.
• W4382893802 hasAuthorship W4382893802A5059900250 @default.
• W4382893802 hasAuthorship W4382893802A5061108604 @default.
• W4382893802 hasAuthorship W4382893802A5083460285 @default.
• W4382893802 hasAuthorship W4382893802A5090244949 @default.
• W4382893802 hasBestOaLocation W43828938021 @default.
• W4382893802 hasConcept C104317684 @default.
• W4382893802 hasConcept C138885662 @default.
• W4382893802 hasConcept C150194340 @default.
• W4382893802 hasConcept C190727270 @default.
• W4382893802 hasConcept C21036866 @default.
• W4382893802 hasConcept C33288867 @default.
• W4382893802 hasConcept C41091548 @default.
• W4382893802 hasConcept C41895202 @default.
• W4382893802 hasConcept C54355233 @default.
• W4382893802 hasConcept C552990157 @default.
• W4382893802 hasConcept C60644358 @default.
• W4382893802 hasConcept C86803240 @default.
• W4382893802 hasConceptScore W4382893802C104317684 @default.
• W4382893802 hasConceptScore W4382893802C138885662 @default.
• W4382893802 hasConceptScore W4382893802C150194340 @default.
• W4382893802 hasConceptScore W4382893802C190727270 @default.
• W4382893802 hasConceptScore W4382893802C21036866 @default.
• W4382893802 hasConceptScore W4382893802C33288867 @default.
• W4382893802 hasConceptScore W4382893802C41091548 @default.
• W4382893802 hasConceptScore W4382893802C41895202 @default.
• W4382893802 hasConceptScore W4382893802C54355233 @default.
• W4382893802 hasConceptScore W4382893802C552990157 @default.
• W4382893802 hasConceptScore W4382893802C60644358 @default.
• W4382893802 hasConceptScore W4382893802C86803240 @default.
• W4382893802 hasFunder F4320337337 @default.
• W4382893802 hasFunder F4320337472 @default.
• W4382893802 hasIssue "1" @default.
• W4382893802 hasLocation W43828938021 @default.
• W4382893802 hasLocation W43828938022 @default.

• next