FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382894252> ?p ?o ?g. }

• W4382894252 abstract "Abstract Protein-protein interactions (PPIs) are crucial for various biological processes, and their prediction is typically accomplished through experimental methods, which can be time-consuming and costly. Computational methods provide a faster and more cost-effective approach, leveraging protein sequences and other data sources to infer PPIs. Deep learning (DL) approaches have shown promising results in various protein-related tasks, including PPI prediction. However, DL-based embeddings are often not thoroughly compared or evaluated against state-of-the-art tools. Additionally, existing PPI predictors incorporate different types of information beyond protein sequence representation, making it important to assess the effectiveness of DL-based embeddings solely relying on protein sequences. In this work, we benchmark and compare commonly used DL-based embeddings for PPI prediction based solely on protein sequence information. We utilize high-quality training data, including experimentally validated negative interactions from the Negatome database. The best model, obtained through double cross-validation and hyperparameter optimization, is selected and evaluated to predict peroxisomal PPIs. The resulting tool, P-PPI, is further enhanced by combining AlphaFold2-Multimer predictions with the P-PPI model, leveraging DL-based embeddings and protein structure predictions for a comprehensive analysis of peroxisomal PPIs. This integrated approach holds significant potential to advance our understanding of complex protein networks and their functions." @default.
• W4382894252 created "2023-07-03" @default.
• W4382894252 creator A5006289055 @default.
• W4382894252 creator A5018442850 @default.
• W4382894252 creator A5030625153 @default.
• W4382894252 date "2023-07-02" @default.
• W4382894252 modified "2023-10-16" @default.
• W4382894252 title "P-PPI: accurate prediction of peroxisomal protein-protein interactions (P-PPI) using deep learning-based protein sequence embeddings" @default.
• W4382894252 cites W1991953772 @default.
• W4382894252 cites W1993046136 @default.
• W4382894252 cites W2048778654 @default.
• W4382894252 cites W2053752564 @default.
• W4382894252 cites W2064675550 @default.
• W4382894252 cites W2076048958 @default.
• W4382894252 cites W2090790364 @default.
• W4382894252 cites W2102461176 @default.
• W4382894252 cites W2102557954 @default.
• W4382894252 cites W2130479394 @default.
• W4382894252 cites W2139279375 @default.
• W4382894252 cites W2140673705 @default.
• W4382894252 cites W2142082526 @default.
• W4382894252 cites W2142678478 @default.
• W4382894252 cites W2167851075 @default.
• W4382894252 cites W2618529956 @default.
• W4382894252 cites W2620760558 @default.
• W4382894252 cites W2724863579 @default.
• W4382894252 cites W2730968108 @default.
• W4382894252 cites W2940565759 @default.
• W4382894252 cites W2948220209 @default.
• W4382894252 cites W2950466381 @default.
• W4382894252 cites W2980789587 @default.
• W4382894252 cites W2995514860 @default.
• W4382894252 cites W3004238495 @default.
• W4382894252 cites W3023807481 @default.
• W4382894252 cites W3112376646 @default.
• W4382894252 cites W3124974365 @default.
• W4382894252 cites W3146944767 @default.
• W4382894252 cites W3177828909 @default.
• W4382894252 cites W3202105508 @default.
• W4382894252 cites W4207018689 @default.
• W4382894252 cites W4220824576 @default.
• W4382894252 cites W4220851257 @default.
• W4382894252 cites W4225264859 @default.
• W4382894252 cites W4236236547 @default.
• W4382894252 cites W4239091587 @default.
• W4382894252 cites W4281742422 @default.
• W4382894252 cites W4292089263 @default.
• W4382894252 cites W4296700210 @default.
• W4382894252 cites W4304731451 @default.
• W4382894252 cites W4318307503 @default.
• W4382894252 doi "https://doi.org/10.1101/2023.06.30.547177" @default.
• W4382894252 hasPublicationYear "2023" @default.
• W4382894252 type Work @default.
• W4382894252 citedByCount "0" @default.
• W4382894252 crossrefType "posted-content" @default.
• W4382894252 hasAuthorship W4382894252A5006289055 @default.
• W4382894252 hasAuthorship W4382894252A5018442850 @default.
• W4382894252 hasAuthorship W4382894252A5030625153 @default.
• W4382894252 hasBestOaLocation W43828942521 @default.
• W4382894252 hasConcept C108583219 @default.
• W4382894252 hasConcept C11804247 @default.
• W4382894252 hasConcept C119857082 @default.
• W4382894252 hasConcept C124101348 @default.
• W4382894252 hasConcept C13280743 @default.
• W4382894252 hasConcept C154945302 @default.
• W4382894252 hasConcept C17744445 @default.
• W4382894252 hasConcept C185798385 @default.
• W4382894252 hasConcept C199539241 @default.
• W4382894252 hasConcept C205649164 @default.
• W4382894252 hasConcept C2776359362 @default.
• W4382894252 hasConcept C2778112365 @default.
• W4382894252 hasConcept C41008148 @default.
• W4382894252 hasConcept C55493867 @default.
• W4382894252 hasConcept C70721500 @default.
• W4382894252 hasConcept C8642999 @default.
• W4382894252 hasConcept C86803240 @default.
• W4382894252 hasConcept C94625758 @default.
• W4382894252 hasConceptScore W4382894252C108583219 @default.
• W4382894252 hasConceptScore W4382894252C11804247 @default.
• W4382894252 hasConceptScore W4382894252C119857082 @default.
• W4382894252 hasConceptScore W4382894252C124101348 @default.
• W4382894252 hasConceptScore W4382894252C13280743 @default.
• W4382894252 hasConceptScore W4382894252C154945302 @default.
• W4382894252 hasConceptScore W4382894252C17744445 @default.
• W4382894252 hasConceptScore W4382894252C185798385 @default.
• W4382894252 hasConceptScore W4382894252C199539241 @default.
• W4382894252 hasConceptScore W4382894252C205649164 @default.
• W4382894252 hasConceptScore W4382894252C2776359362 @default.
• W4382894252 hasConceptScore W4382894252C2778112365 @default.
• W4382894252 hasConceptScore W4382894252C41008148 @default.
• W4382894252 hasConceptScore W4382894252C55493867 @default.
• W4382894252 hasConceptScore W4382894252C70721500 @default.
• W4382894252 hasConceptScore W4382894252C8642999 @default.
• W4382894252 hasConceptScore W4382894252C86803240 @default.
• W4382894252 hasConceptScore W4382894252C94625758 @default.
• W4382894252 hasLocation W43828942521 @default.
• W4382894252 hasOpenAccess W4382894252 @default.
• W4382894252 hasPrimaryLocation W43828942521 @default.
• W4382894252 hasRelatedWork W3081580854 @default.
• W4382894252 hasRelatedWork W4210794429 @default.

• next