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- W4382918107 abstract "Highly contagious respiratory illnesses like influenza and COVID-19 pose serious risks to public health. A two-in-one vaccine would be ideal to avoid multiple vaccinations for these diseases. Here, we generated a chimeric receptor binding domain of the spike protein (S-RBD) and hemagglutinin (HA)-stalk-based vaccine for both SARS-CoV-2 and influenza viruses. The S-RBD from SARS-CoV-2 Delta was fused to the headless HA from H1N1 (H1Delta), creating a chimera that forms trimers in solution. The cryo-electron microscopy structure of the chimeric protein complexed with the RBD-targeting CB6 and the HA-stalk-targeting CR9114 antibodies shows that the trimeric protein is stable and accessible for neutralizing antibody binding. Immunization with the vaccine elicited high and long-lasting neutralizing antibodies and effectively protected mice against the challenges of lethal H1N1 or heterosubtypic H5N8, as well as the SARS-CoV-2 Delta or Omicron BA.2 variants. Overall, this study offers a two-in-one universal vaccine design to combat infections caused by both SARS-CoV-2 variants of concern and influenza viruses." @default.
- W4382918107 created "2023-07-04" @default.
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- W4382918107 date "2023-07-13" @default.
- W4382918107 modified "2023-10-17" @default.
- W4382918107 title "Rational design of an influenza-COVID-19 chimeric protective vaccine with HA-stalk and S-RBD" @default.
- W4382918107 cites W1816587284 @default.
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- W4382918107 cites W1985704471 @default.
- W4382918107 cites W1996311210 @default.
- W4382918107 cites W2001089308 @default.
- W4382918107 cites W2002632348 @default.
- W4382918107 cites W2006840424 @default.
- W4382918107 cites W2038618099 @default.
- W4382918107 cites W2040440325 @default.
- W4382918107 cites W2102335249 @default.
- W4382918107 cites W2104391453 @default.
- W4382918107 cites W2121009566 @default.
- W4382918107 cites W2129191377 @default.
- W4382918107 cites W2130737480 @default.
- W4382918107 cites W2132629607 @default.
- W4382918107 cites W2152617913 @default.
- W4382918107 cites W2157116486 @default.
- W4382918107 cites W2163135112 @default.
- W4382918107 cites W2164807254 @default.
- W4382918107 cites W2491683774 @default.
- W4382918107 cites W2587625522 @default.
- W4382918107 cites W2593511418 @default.
- W4382918107 cites W2605082299 @default.
- W4382918107 cites W2792009592 @default.
- W4382918107 cites W2792024998 @default.
- W4382918107 cites W2806230602 @default.
- W4382918107 cites W2886468311 @default.
- W4382918107 cites W2896676527 @default.
- W4382918107 cites W2899714098 @default.
- W4382918107 cites W2938046908 @default.
- W4382918107 cites W2953320394 @default.
- W4382918107 cites W2963349853 @default.
- W4382918107 cites W2986468352 @default.
- W4382918107 cites W3001897055 @default.
- W4382918107 cites W3005494427 @default.
- W4382918107 cites W3013893137 @default.
- W4382918107 cites W3026558549 @default.
- W4382918107 cites W3032255042 @default.
- W4382918107 cites W3037923073 @default.
- W4382918107 cites W3084852403 @default.
- W4382918107 cites W3111038302 @default.
- W4382918107 cites W3117730334 @default.
- W4382918107 cites W3119127733 @default.
- W4382918107 cites W3128133654 @default.
- W4382918107 cites W3129733558 @default.
- W4382918107 cites W3167600642 @default.
- W4382918107 cites W3174588468 @default.
- W4382918107 cites W3175969873 @default.
- W4382918107 cites W3181157775 @default.
- W4382918107 cites W3208822418 @default.
- W4382918107 cites W4200306955 @default.
- W4382918107 cites W4210674949 @default.
- W4382918107 cites W4214913767 @default.
- W4382918107 cites W4221092503 @default.
- W4382918107 cites W4224950176 @default.
- W4382918107 cites W4226027283 @default.
- W4382918107 cites W4281561106 @default.
- W4382918107 cites W4281664348 @default.
- W4382918107 cites W4284714502 @default.
- W4382918107 cites W4285093753 @default.
- W4382918107 cites W4293217024 @default.
- W4382918107 cites W4295776561 @default.
- W4382918107 cites W4296139691 @default.
- W4382918107 cites W4297817274 @default.
- W4382918107 cites W4366371376 @default.
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- W4382918107 doi "https://doi.org/10.1080/22221751.2023.2231573" @default.
- W4382918107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37394992" @default.
- W4382918107 hasPublicationYear "2023" @default.
- W4382918107 type Work @default.