Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382927706> ?p ?o ?g. }
- W4382927706 abstract "Osteochondral regeneration remains a great challenge due to the limited self-healing ability and the complexity of its hierarchical structure and composition. Mg2+ and hypoxia are two effective modulators in boosting chondrogenesis. To this end, a double-layered scaffold (D) consisting of a hydrogel layer on a porous cryogel is fabricated to mimic the hierarchical structure of osteochondral tissue. An Mg2+ gradient is incorporated into the double-layered scaffold with hypoxia-mimicking deferoxamine (DFO) embedded in the hydrogel (D-Mg-DFO), which remarkably augments the dual-lineage regeneration of both cartilage and subchondral bone. The higher Mg2+ supplementation from the upper hydrogel, associated with its hypoxia-mimicking situation and small pore size, exhibits promotive effects on chondrogenic differentiation. The lower Mg2+ supplementation from the bottom cryogel, associated with its interconnected macroporous structure, achieves multiple contributions in stem cell migration from bone marrow cavity, matrix mineralization, and osteogenesis. Furthermore, rabbits’ trochlea osteochondral defects are established to evaluate the regenerative outcome. Compared to control scaffolds containing only Mg2+ or DFO, the D-Mg-DFO scaffold presents the best regenerative effect under the synergistic contribution of multiple factors. Overall, this work provides a new design of scaffold toward an effective repair of cartilage defect." @default.
- W4382927706 created "2023-07-04" @default.
- W4382927706 creator A5000596190 @default.
- W4382927706 creator A5001717213 @default.
- W4382927706 creator A5006651636 @default.
- W4382927706 creator A5021984184 @default.
- W4382927706 creator A5033632697 @default.
- W4382927706 creator A5034964028 @default.
- W4382927706 creator A5052100202 @default.
- W4382927706 creator A5056148571 @default.
- W4382927706 creator A5060748108 @default.
- W4382927706 creator A5065804668 @default.
- W4382927706 creator A5070666229 @default.
- W4382927706 date "2023-07-02" @default.
- W4382927706 modified "2023-10-15" @default.
- W4382927706 title "Magnesium Gradient‐Based Hierarchical Scaffold for Dual‐Lineage Regeneration of Osteochondral Defect" @default.
- W4382927706 cites W1980143338 @default.
- W4382927706 cites W1986617777 @default.
- W4382927706 cites W2023374146 @default.
- W4382927706 cites W2037539968 @default.
- W4382927706 cites W2052682012 @default.
- W4382927706 cites W2061790831 @default.
- W4382927706 cites W2157951056 @default.
- W4382927706 cites W2159210886 @default.
- W4382927706 cites W2172031022 @default.
- W4382927706 cites W2195116818 @default.
- W4382927706 cites W2251700411 @default.
- W4382927706 cites W2623981860 @default.
- W4382927706 cites W2801710223 @default.
- W4382927706 cites W2892745625 @default.
- W4382927706 cites W2897084149 @default.
- W4382927706 cites W2903249634 @default.
- W4382927706 cites W2905151968 @default.
- W4382927706 cites W2946370455 @default.
- W4382927706 cites W2959527885 @default.
- W4382927706 cites W2974837212 @default.
- W4382927706 cites W2977795968 @default.
- W4382927706 cites W2978366279 @default.
- W4382927706 cites W3021164543 @default.
- W4382927706 cites W3042997153 @default.
- W4382927706 cites W3049124952 @default.
- W4382927706 cites W3103508357 @default.
- W4382927706 cites W3122383453 @default.
- W4382927706 cites W3133881043 @default.
- W4382927706 cites W3136224130 @default.
- W4382927706 cites W3136761903 @default.
- W4382927706 cites W3137078406 @default.
- W4382927706 cites W3144301738 @default.
- W4382927706 cites W3164496937 @default.
- W4382927706 cites W3213604708 @default.
- W4382927706 cites W3216205927 @default.
- W4382927706 cites W4200513221 @default.
- W4382927706 cites W4206695395 @default.
- W4382927706 cites W4207005916 @default.
- W4382927706 cites W4210582766 @default.
- W4382927706 cites W4213081997 @default.
- W4382927706 cites W4214868947 @default.
- W4382927706 cites W4220682802 @default.
- W4382927706 cites W4220872119 @default.
- W4382927706 cites W4220984818 @default.
- W4382927706 cites W4223938496 @default.
- W4382927706 cites W4283459955 @default.
- W4382927706 cites W4283763856 @default.
- W4382927706 cites W4283821125 @default.
- W4382927706 cites W4284690118 @default.
- W4382927706 cites W4293102937 @default.
- W4382927706 cites W4295648542 @default.
- W4382927706 cites W4296520864 @default.
- W4382927706 cites W4310816572 @default.
- W4382927706 cites W4311549977 @default.
- W4382927706 cites W4312213891 @default.
- W4382927706 cites W4313323169 @default.
- W4382927706 cites W4313490979 @default.
- W4382927706 cites W4313558102 @default.
- W4382927706 cites W4315471328 @default.
- W4382927706 cites W4318562180 @default.
- W4382927706 cites W4321373267 @default.
- W4382927706 cites W4323073613 @default.
- W4382927706 cites W4366603141 @default.
- W4382927706 doi "https://doi.org/10.1002/adfm.202304829" @default.
- W4382927706 hasPublicationYear "2023" @default.
- W4382927706 type Work @default.
- W4382927706 citedByCount "0" @default.
- W4382927706 crossrefType "journal-article" @default.
- W4382927706 hasAuthorship W4382927706A5000596190 @default.
- W4382927706 hasAuthorship W4382927706A5001717213 @default.
- W4382927706 hasAuthorship W4382927706A5006651636 @default.
- W4382927706 hasAuthorship W4382927706A5021984184 @default.
- W4382927706 hasAuthorship W4382927706A5033632697 @default.
- W4382927706 hasAuthorship W4382927706A5034964028 @default.
- W4382927706 hasAuthorship W4382927706A5052100202 @default.
- W4382927706 hasAuthorship W4382927706A5056148571 @default.
- W4382927706 hasAuthorship W4382927706A5060748108 @default.
- W4382927706 hasAuthorship W4382927706A5065804668 @default.
- W4382927706 hasAuthorship W4382927706A5070666229 @default.
- W4382927706 hasConcept C105702510 @default.
- W4382927706 hasConcept C136229726 @default.
- W4382927706 hasConcept C171056886 @default.
- W4382927706 hasConcept C192562407 @default.
- W4382927706 hasConcept C2780550940 @default.