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- W4382932829 abstract "Human congenital disorders are often linked to genomic structural variations within the germline caused by DNA amplifications and deletions1. The fate of deleted DNA however in most recurrent germline deletions is not explained. Previous work on normal somatic cells and cancer cells shows that deleted DNA can circularize and exist as self-replicating elements2-4. Such extrachromosomal circular DNA (eccDNA) is common in eukaryotic species, derives from all parts of the genome, and may contain entire genes or non-coding regulatory elements such as small RNAs. However, little is known about the role eccDNA plays in germline cells." @default.
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- W4382932829 date "2023-07-01" @default.
- W4382932829 modified "2023-09-25" @default.
- W4382932829 title "EXTRACHROMOSOMAL CIRCULAR DNA IN MALE GERMLINE CELLS" @default.
- W4382932829 doi "https://doi.org/10.1016/j.fertnstert.2023.05.103" @default.
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