FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382936698> ?p ?o ?g. }

• W4382936698 endingPage "5184" @default.
• W4382936698 startingPage "5184" @default.
• W4382936698 abstract "Malaria and schistosomiasis are two of the neglected tropical diseases that persistently wreak havoc worldwide. Although many antimalarial drugs such as chloroquine are readily available, the emergence of drug resistance necessitates the development of new therapies to combat this disease. Conversely, Praziquantel (PZQ) remains the sole effective drug against schistosomiasis, but its extensive use raises concerns about the potential for drug resistance to develop. In this project, the concept of molecular hybridization was used as a strategy to design the synthesis of new molecular hybrids with potential antimalarial and antischistosomal activity. A total of seventeen molecular hybrids and two PZQ analogues were prepared by coupling 6-alkylpraziquanamines with cinnamic acids and cyclohexane carboxylic acid, respectively. The synthesised compounds were evaluated for their antimalarial and antischistosomal activity; while all of the above compounds were inactive against Plasmodium falciparum (IC50 > 6 µM), many were active against schistosomiasis with four particular compounds exhibiting up to 100% activity against newly transformed schistosomula and adult worms at 50 µM. Compared to PZQ, the reference drug, the activity of which is 91.7% at 1 µM, one particular molecular hybrid, compound 32, which bears a para-isopropyl group on the cinnamic acid moiety, exhibited a notable activity at 10 µM (78.2% activity). This compound has emerged as the front runner candidate that might, after further optimization, hold promise as a potential lead compound in the fight against schistosomiasis." @default.
• W4382936698 created "2023-07-04" @default.
• W4382936698 creator A5008906969 @default.
• W4382936698 creator A5020904998 @default.
• W4382936698 creator A5033452459 @default.
• W4382936698 creator A5059824515 @default.
• W4382936698 date "2023-07-03" @default.
• W4382936698 modified "2023-10-14" @default.
• W4382936698 title "Design, Synthesis and Evaluation of Praziquantel Analogues and New Molecular Hybrids as Potential Antimalarial and Anti-Schistosomal Agents" @default.
• W4382936698 cites W1965049762 @default.
• W4382936698 cites W1974675455 @default.
• W4382936698 cites W1978947246 @default.
• W4382936698 cites W1991474023 @default.
• W4382936698 cites W2006252452 @default.
• W4382936698 cites W2008116313 @default.
• W4382936698 cites W2027182392 @default.
• W4382936698 cites W2030379622 @default.
• W4382936698 cites W2158340391 @default.
• W4382936698 cites W2164460325 @default.
• W4382936698 cites W2166039858 @default.
• W4382936698 cites W2170657871 @default.
• W4382936698 cites W2178929000 @default.
• W4382936698 cites W2180971085 @default.
• W4382936698 cites W2255841639 @default.
• W4382936698 cites W2296263363 @default.
• W4382936698 cites W2599189039 @default.
• W4382936698 cites W2601248022 @default.
• W4382936698 cites W2608100473 @default.
• W4382936698 cites W2742609028 @default.
• W4382936698 cites W2761376769 @default.
• W4382936698 cites W2905809885 @default.
• W4382936698 cites W2907241206 @default.
• W4382936698 cites W2950124390 @default.
• W4382936698 cites W2955037230 @default.
• W4382936698 cites W3012414214 @default.
• W4382936698 cites W3014107563 @default.
• W4382936698 cites W3088515432 @default.
• W4382936698 cites W3092013103 @default.
• W4382936698 cites W3141339282 @default.
• W4382936698 cites W4211093028 @default.
• W4382936698 cites W4211145066 @default.
• W4382936698 cites W4308959213 @default.
• W4382936698 cites W4309858921 @default.
• W4382936698 cites W4327921929 @default.
• W4382936698 doi "https://doi.org/10.3390/molecules28135184" @default.
• W4382936698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37446846" @default.
• W4382936698 hasPublicationYear "2023" @default.
• W4382936698 type Work @default.
• W4382936698 citedByCount "0" @default.
• W4382936698 crossrefType "journal-article" @default.
• W4382936698 hasAuthorship W4382936698A5008906969 @default.
• W4382936698 hasAuthorship W4382936698A5020904998 @default.
• W4382936698 hasAuthorship W4382936698A5033452459 @default.
• W4382936698 hasAuthorship W4382936698A5059824515 @default.
• W4382936698 hasBestOaLocation W43829366981 @default.
• W4382936698 hasConcept C114851261 @default.
• W4382936698 hasConcept C165901193 @default.
• W4382936698 hasConcept C185592680 @default.
• W4382936698 hasConcept C18903297 @default.
• W4382936698 hasConcept C203014093 @default.
• W4382936698 hasConcept C2776225656 @default.
• W4382936698 hasConcept C2776908094 @default.
• W4382936698 hasConcept C2778048844 @default.
• W4382936698 hasConcept C2779744950 @default.
• W4382936698 hasConcept C2780035454 @default.
• W4382936698 hasConcept C55493867 @default.
• W4382936698 hasConcept C556039675 @default.
• W4382936698 hasConcept C71240020 @default.
• W4382936698 hasConcept C71924100 @default.
• W4382936698 hasConcept C74187038 @default.
• W4382936698 hasConcept C86803240 @default.
• W4382936698 hasConcept C89423630 @default.
• W4382936698 hasConcept C98274493 @default.
• W4382936698 hasConceptScore W4382936698C114851261 @default.
• W4382936698 hasConceptScore W4382936698C165901193 @default.
• W4382936698 hasConceptScore W4382936698C185592680 @default.
• W4382936698 hasConceptScore W4382936698C18903297 @default.
• W4382936698 hasConceptScore W4382936698C203014093 @default.
• W4382936698 hasConceptScore W4382936698C2776225656 @default.
• W4382936698 hasConceptScore W4382936698C2776908094 @default.
• W4382936698 hasConceptScore W4382936698C2778048844 @default.
• W4382936698 hasConceptScore W4382936698C2779744950 @default.
• W4382936698 hasConceptScore W4382936698C2780035454 @default.
• W4382936698 hasConceptScore W4382936698C55493867 @default.
• W4382936698 hasConceptScore W4382936698C556039675 @default.
• W4382936698 hasConceptScore W4382936698C71240020 @default.
• W4382936698 hasConceptScore W4382936698C71924100 @default.
• W4382936698 hasConceptScore W4382936698C74187038 @default.
• W4382936698 hasConceptScore W4382936698C86803240 @default.
• W4382936698 hasConceptScore W4382936698C89423630 @default.
• W4382936698 hasConceptScore W4382936698C98274493 @default.
• W4382936698 hasIssue "13" @default.
• W4382936698 hasLocation W43829366981 @default.
• W4382936698 hasLocation W43829366982 @default.
• W4382936698 hasLocation W43829366983 @default.
• W4382936698 hasOpenAccess W4382936698 @default.
• W4382936698 hasPrimaryLocation W43829366981 @default.
• W4382936698 hasRelatedWork W1485239507 @default.

• next