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• W4382937648 abstract "Abstract Background In hematologic cancers, including leukemia, cells depend on amino acids for rapid growth. Anti-metabolites that prevent their synthesis or promote their degradation are considered potential cancer treatment agents. Amino acid deprivation triggers proliferation inhibition, autophagy, and programmed cell death. Lysine, an essential amino acid, is required for tumor growth and has been investigated for its potential as a target for cancer treatment. L-lysine-α-oxidase, a flavoenzyme that degrades lysine, has been studied for its ability to induce apoptosis and prevent cancer cell proliferation. In this study, we describe the use of L-lysine oxidase (LO) from the filamentous fungus Trichoderma harzianum for cancer treatment. Results The study identified and characterized a novel LO from T. harzianum and demonstrated that the recombinant protein (rLO) has potent and selective cytotoxic effects on leukemic cells by triggering the apoptotic cascade through mitochondrial dysfunction. Conclusions The results support future translational studies using the recombinant LO as a potential drug for the treatment of leukemia." @default.
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• W4382937648 date "2023-07-03" @default.
• W4382937648 modified "2023-10-01" @default.
• W4382937648 title "The recombinant L-Lysine α-oxidase from the fungus Trichoderma harzianum promotes apoptosis and necrosis of leukemia CD34+ hematopoietic cells" @default.
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• W4382937648 doi "https://doi.org/10.21203/rs.3.rs-3115901/v1" @default.
• W4382937648 hasPublicationYear "2023" @default.
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