FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382938129> ?p ?o ?g. }

• W4382938129 abstract "Abstract Background It is unclear whether dobutamine, commonly used clinically in echocardiography and short-term congestive heart failure treatment for promoting increased myocardial contractility, affects brain microcirculatory behavior. Cerebral microcirculation plays an important role in ensuring adequate oxygen transport. Therefore, we investigated the effects of dobutamine on cerebral hemodynamics. Methods Forty-eight healthy volunteers without cardiovascular or cerebrovascular disease underwent MRI to obtain cerebral blood flow (CBF) maps using 3D pseudocontinuous arterial spin labeling before and during the dobutamine stress test. Additionally, cerebrovascular morphology was obtained based on 3D-time-off-light (3D-TOF) magnetic resonance angiography (MRA). Electrocardiogram, heart rate (HR), respiration rate (RR), blood pressure, and blood oxygen were simultaneously recorded before and during dobutamine injection and during recovery (not during MRI). The anatomic features of the circle of Willis and the basilar artery (BA) diameter were assessed on MRA images by two radiologists with extensive neuroimaging experience. Binary logistic regression was used to test for the independent determinants of CBF changes. Results HR, RR, systolic (SBP), and diastolic blood pressure (DBP) significantly increased after dobutamine infusion. Blood oxygen levels remained similar. Compared to the CBF in the resting state, the CBF values exhibited significantly lower CBF levels in both grey matter and white matter. Furthermore, compared with the CBF in the resting state, that in the stress state was decreased in the anterior circulation, mainly in the frontal lobe (voxel level P < 0.001, pixel level P < 0.05). Logistic regression showed that body mass index (BMI; odds ratio [OR] 5.80, 95% confidence interval [CI] 1.60–21.01, P = 0.008], resting SBP (OR 0.64, 95% CI 0.45–0.92, P = 0.014), and BA diameter (OR 11.04, 95% CI 1.05–116.53, P = 0.046) were significantly associated with frontal lobe CBF changes. Conclusions Dobutamine-induced stress significantly decreased CBF in the frontal lobe anterior circulation. Individuals with a high BMI and low SBP during the dobutamine stress test are more likely to have a stress-induced CBF decrease. Thus, attention should be paid to blood pressure, BMI, and cerebrovascular morphology of patients undergoing dobutamine stress echocardiography or those receiving intensive care or anesthesia." @default.
• W4382938129 created "2023-07-04" @default.
• W4382938129 creator A5006014871 @default.
• W4382938129 creator A5007970331 @default.
• W4382938129 creator A5008008825 @default.
• W4382938129 creator A5015737946 @default.
• W4382938129 creator A5015877351 @default.
• W4382938129 creator A5042486475 @default.
• W4382938129 creator A5051745837 @default.
• W4382938129 creator A5052630982 @default.
• W4382938129 creator A5070151668 @default.
• W4382938129 creator A5073566127 @default.
• W4382938129 creator A5075261929 @default.
• W4382938129 creator A5077913648 @default.
• W4382938129 creator A5083907609 @default.
• W4382938129 date "2023-07-03" @default.
• W4382938129 modified "2023-10-17" @default.
• W4382938129 title "Dobutamine-induced alternations in cerebral blood flow of healthy adults: a 3D pseudocontinuous arterial spin labeling study" @default.
• W4382938129 cites W1554470096 @default.
• W4382938129 cites W1560769507 @default.
• W4382938129 cites W1565795219 @default.
• W4382938129 cites W1943111202 @default.
• W4382938129 cites W1944323188 @default.
• W4382938129 cites W1980385871 @default.
• W4382938129 cites W1990827594 @default.
• W4382938129 cites W2003014357 @default.
• W4382938129 cites W2010812056 @default.
• W4382938129 cites W2021442736 @default.
• W4382938129 cites W2022467453 @default.
• W4382938129 cites W2025209227 @default.
• W4382938129 cites W2028390341 @default.
• W4382938129 cites W2031999325 @default.
• W4382938129 cites W2035403976 @default.
• W4382938129 cites W2040589147 @default.
• W4382938129 cites W2040622355 @default.
• W4382938129 cites W2056256944 @default.
• W4382938129 cites W2070449723 @default.
• W4382938129 cites W2071110069 @default.
• W4382938129 cites W2084517463 @default.
• W4382938129 cites W2084639468 @default.
• W4382938129 cites W2118516235 @default.
• W4382938129 cites W2120338775 @default.
• W4382938129 cites W2129671974 @default.
• W4382938129 cites W2152159230 @default.
• W4382938129 cites W2153873864 @default.
• W4382938129 cites W2154394735 @default.
• W4382938129 cites W2155963307 @default.
• W4382938129 cites W2166780755 @default.
• W4382938129 cites W2168755046 @default.
• W4382938129 cites W2537481264 @default.
• W4382938129 cites W2567213206 @default.
• W4382938129 cites W2755692965 @default.
• W4382938129 cites W2845366601 @default.
• W4382938129 cites W2885427980 @default.
• W4382938129 cites W2900649959 @default.
• W4382938129 cites W2930277906 @default.
• W4382938129 cites W2952316075 @default.
• W4382938129 cites W2972604459 @default.
• W4382938129 cites W2979752265 @default.
• W4382938129 cites W3006620255 @default.
• W4382938129 cites W3026895770 @default.
• W4382938129 cites W3044317574 @default.
• W4382938129 cites W3047205337 @default.
• W4382938129 cites W3164883349 @default.
• W4382938129 cites W3193439639 @default.
• W4382938129 cites W4281479452 @default.
• W4382938129 cites W4291016309 @default.
• W4382938129 doi "https://doi.org/10.1186/s12916-023-02928-1" @default.
• W4382938129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37400817" @default.
• W4382938129 hasPublicationYear "2023" @default.
• W4382938129 type Work @default.
• W4382938129 citedByCount "0" @default.
• W4382938129 crossrefType "journal-article" @default.
• W4382938129 hasAuthorship W4382938129A5006014871 @default.
• W4382938129 hasAuthorship W4382938129A5007970331 @default.
• W4382938129 hasAuthorship W4382938129A5008008825 @default.
• W4382938129 hasAuthorship W4382938129A5015737946 @default.
• W4382938129 hasAuthorship W4382938129A5015877351 @default.
• W4382938129 hasAuthorship W4382938129A5042486475 @default.
• W4382938129 hasAuthorship W4382938129A5051745837 @default.
• W4382938129 hasAuthorship W4382938129A5052630982 @default.
• W4382938129 hasAuthorship W4382938129A5070151668 @default.
• W4382938129 hasAuthorship W4382938129A5073566127 @default.
• W4382938129 hasAuthorship W4382938129A5075261929 @default.
• W4382938129 hasAuthorship W4382938129A5077913648 @default.
• W4382938129 hasAuthorship W4382938129A5083907609 @default.
• W4382938129 hasBestOaLocation W43829381291 @default.
• W4382938129 hasConcept C126322002 @default.
• W4382938129 hasConcept C126838900 @default.
• W4382938129 hasConcept C143409427 @default.
• W4382938129 hasConcept C157767197 @default.
• W4382938129 hasConcept C164705383 @default.
• W4382938129 hasConcept C178853913 @default.
• W4382938129 hasConcept C2777953023 @default.
• W4382938129 hasConcept C2781185063 @default.
• W4382938129 hasConcept C42219234 @default.
• W4382938129 hasConcept C71924100 @default.
• W4382938129 hasConcept C84393581 @default.
• W4382938129 hasConceptScore W4382938129C126322002 @default.
• W4382938129 hasConceptScore W4382938129C126838900 @default.

• next