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- W4382940173 abstract "Currently, anti-PD-1/PD-L1 immunotherapy using immune checkpoint inhibitors is widely used in the treatment of multiple cancer types including lung cancer, which is a leading cause of cancer death in the world. However, only a limited proportion of lung cancer patients will benefit from anti-PD-1/PD-L1 therapy. Therefore, it is of importance to predict the response to immunotherapy for the precision treatment of patients. Although the expression of PD-L1 and tumor mutation burden (TMB) are commonly used to predict the clinical response of anti-PD-1/PD-L1 therapy, other factors such as tumor-specific genes, dMMR/MSI, and gut microbiome are also promising predictors for immunotherapy in lung cancer. Furthermore, invasive peripheral blood biomarkers including blood DNA-related biomarkers (e.g., ctDNA and bTMB), blood cell-related biomarkers (e.g., immune cells and TCR), and other blood-related biomarkers (e.g., soluble PD-L1 and cytokines) were utilized to predict the immunotherapeutic response. In this review, the current achievements of anti-PD-1/PD-L1 therapy and the potential biomarkers for the prediction of anti-PD-1/PD-L1 immunotherapy in lung cancer treatment were summarized and discussed." @default.
- W4382940173 created "2023-07-04" @default.
- W4382940173 creator A5011090502 @default.
- W4382940173 creator A5026310549 @default.
- W4382940173 creator A5032026879 @default.
- W4382940173 creator A5042282225 @default.
- W4382940173 creator A5042956973 @default.
- W4382940173 creator A5075888726 @default.
- W4382940173 creator A5083958093 @default.
- W4382940173 date "2023-07-03" @default.
- W4382940173 modified "2023-09-25" @default.
- W4382940173 title "Research progress of biomarkers in the prediction of anti-PD-1/PD-L1 immunotherapeutic efficiency in lung cancer" @default.
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