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• W4382987700 abstract "Abstract Purpose This study aimed to investigate the diagnostic performance of T-CT, following Radiological Society of North America (RSNA) recommendations, in patients with suspected Covid-19 and pulmonary infiltrations established in T-CT scans. Methods From March to August 2020, a total of 324 patients who were suspected of having COVID-19 and had undergone T-CT scans for various indications at the emergency department (ED) were included in the study. Two blinded radiologists independently reviewed all T-CT scans and categorized the infiltration features based on the RSNA recommendations. The reference diagnostic test for COVID-19 was the reverse-transcriptase polymerase chain reaction (RT-PCR). To evaluate the diagnostic performance of T-CT, different T-CT categories were considered as thresholds. Results 112 (35%) of 324 patients had positive RT-PCR results. After the LCA, the final T-CT category was typical for 114 patients (35.2%), indeterminate for 154 patients (47.5%), and atypical for 36 patients (11.1%). The results showed that utilizing the typical T-CT category as a positive-negative threshold yielded a sensitivity of 66%, specificity of 81%, positive predictive value (PPV) of 65%, negative predictive value (NPV) of 82%, and accuracy of 76%. In the subgroup analysis of patients who underwent multiple RT-PCR tests, the diagnostic performance improved, with a sensitivity of 80%, specificity of 79%, PPV of 76%, NPV of 83%, and accuracy of 79%. Combined use of RT-PCR and T-CT resulted in a sensitivity of 95.5%, PPV of 79%, and accuracy of 86.4%. Conclusion Based on RSNA consensus guidelines, T-CT shows a moderate sensitivity of 66% and high specificity of 81% for diagnosing Covid-19. In ED settings with suspected cases, T-CT can be helpful in recommending retesting after an initial negative RT-PCR result, facilitating early management, and enabling timely isolation measures. The combined use of RT-PCR and T-CT improves diagnostic performance, highlighting the potential benefits of integrating these methods." @default.
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• W4382987700 date "2023-07-03" @default.
• W4382987700 modified "2023-10-17" @default.
• W4382987700 title "The Relation of Polymerase Chain Reaction and Computed Tomography Infiltrations of Suspected Covid-19 Patients in Emergency Department" @default.
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• W4382987700 doi "https://doi.org/10.21203/rs.3.rs-3077021/v1" @default.
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