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- W4382990156 abstract "Des atteintes hématologiques spécifiques peuvent être observées au décours de différentes hémopathies malignes. L’analyse cytologique du liquide cérébrospinal (LCS) sera donc réalisée dans ce contexte, soit de façon systématique au diagnostic de la maladie, soit en raison de points d’appel cliniques. Si elle reste la pierre angulaire du diagnostic, d’autres examens complémentaires peuvent être utiles au sein d’une approche multidisciplinaire : cytométrie en flux, recherche de clonalité par biologie moléculaire, dosage de cytokines, etc., en fonction de la pathologie. Depuis quelques années, dans le contexte diagnostique d’une masse cérébrale, une analyse du liquide de rinçage de l’aiguille ayant servi à la biopsie stéréotaxique s’est développée, permettant un gain de temps pour l’orientation diagnostique et ayant démontré une excellente concordance avec l’histologie. Specific leptomeningeal involvement can be observed in the course of various hematological malignancies. Cytomorphological analysis of the CSF will therefore be carried out in this context, either systematically at the diagnosis of the disease, or because of clinical symptoms. Despite morphology is still being considered as the gold standard, multimodal investigation of CSF has been developed, especially in lymphoma context. Flow cytometry and molecular analyses show very high sensitivity and specificity and are now part of the routine workflow in several diseases. In recent years, in the differential diagnosis of central nervous system lymphoma, contribution of cytomorphology and flow cytometry analyses of brain biopsy rinse has shown good agreement with histopathology and reveals as a fast and useful strategy." @default.
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- W4382990156 date "2023-07-01" @default.
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- W4382990156 title "Atteinte cérébrospinale des hémopathies malignes" @default.
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