FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382995874> ?p ?o ?g. }

• W4382995874 endingPage "276" @default.
• W4382995874 startingPage "276" @default.
• W4382995874 abstract "Neurotrophin receptor-interacting melanoma-associated antigen homolog (NRAGE), a type II melanoma-associated antigen, plays a critical role in cell processes that are involved in the tumorigenesis of various cancers. However, the effect of NRAGE on acute myeloid leukemia (AML) is rarely reported. The expression of NRAGE in AML tissues and the survival rates between different AML groups were obtained from the GEPIA tool. Human AML cell lines were cultured and transfected with siRNA targeting NRAGE. The ability of AML cells to proliferate and cell cycle were examined. Western blotting was performed to detect the activity of the extracellular signal-regulated kinase (ERK) signaling pathway in AML cells. NRAGE expression was enhanced in AML tissues relative to control tissues, and the high NRAGE expression in AML patients is associated with a poor prognosis. The capacity of AML cells to survive and proliferate was significantly decreased and its cell cycle was arrested at the G1 phase after NRAGE was silenced. Furthermore, silencing NRAGE induced the inactivation of the ERK signaling pathway. Furthermore, supplement of tert-Butylhydroquinone, an ERK activator, improved the reduced ability of AML cell survival and proliferation as well as cell cycle arrest induced by NRAGE knockdown. In this study, NRAGE was identified as a tumor promoter in AML, which had an effect on cell proliferation, cell survival, and cell cycle through the ERK signaling pathway in AML cells." @default.
• W4382995874 created "2023-07-04" @default.
• W4382995874 creator A5027950316 @default.
• W4382995874 creator A5038305059 @default.
• W4382995874 creator A5072591435 @default.
• W4382995874 date "2023-01-01" @default.
• W4382995874 modified "2023-10-17" @default.
• W4382995874 title "Knockdown of neurotrophin receptor-interacting melanoma-associated antigen homolog inhibits acute myeloid leukemia cell growth via the ERK pathway" @default.
• W4382995874 cites W1547736903 @default.
• W4382995874 cites W1977927411 @default.
• W4382995874 cites W2023786025 @default.
• W4382995874 cites W2046024621 @default.
• W4382995874 cites W2049482339 @default.
• W4382995874 cites W2102461774 @default.
• W4382995874 cites W2156763171 @default.
• W4382995874 cites W2264403779 @default.
• W4382995874 cites W2323808474 @default.
• W4382995874 cites W2402659493 @default.
• W4382995874 cites W2509517672 @default.
• W4382995874 cites W2548469661 @default.
• W4382995874 cites W2591153485 @default.
• W4382995874 cites W2607129810 @default.
• W4382995874 cites W2633117067 @default.
• W4382995874 cites W2789314949 @default.
• W4382995874 cites W2804184546 @default.
• W4382995874 cites W2888214283 @default.
• W4382995874 cites W2970658856 @default.
• W4382995874 cites W3006985077 @default.
• W4382995874 cites W3015589734 @default.
• W4382995874 cites W3112754852 @default.
• W4382995874 cites W3127901467 @default.
• W4382995874 cites W3137220512 @default.
• W4382995874 cites W3176802416 @default.
• W4382995874 cites W3177616870 @default.
• W4382995874 cites W3184428661 @default.
• W4382995874 cites W3206638628 @default.
• W4382995874 cites W4200385850 @default.
• W4382995874 cites W4250212255 @default.
• W4382995874 cites W4286241304 @default.
• W4382995874 cites W4288434494 @default.
• W4382995874 doi "https://doi.org/10.4103/cjop.cjop-d-22-00162" @default.
• W4382995874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37635487" @default.
• W4382995874 hasPublicationYear "2023" @default.
• W4382995874 type Work @default.
• W4382995874 citedByCount "0" @default.
• W4382995874 crossrefType "journal-article" @default.
• W4382995874 hasAuthorship W4382995874A5027950316 @default.
• W4382995874 hasAuthorship W4382995874A5038305059 @default.
• W4382995874 hasAuthorship W4382995874A5072591435 @default.
• W4382995874 hasBestOaLocation W43829958741 @default.
• W4382995874 hasConcept C104317684 @default.
• W4382995874 hasConcept C119056186 @default.
• W4382995874 hasConcept C1491633281 @default.
• W4382995874 hasConcept C173396325 @default.
• W4382995874 hasConcept C2778729363 @default.
• W4382995874 hasConcept C29537977 @default.
• W4382995874 hasConcept C502942594 @default.
• W4382995874 hasConcept C54355233 @default.
• W4382995874 hasConcept C55493867 @default.
• W4382995874 hasConcept C57074206 @default.
• W4382995874 hasConcept C62112901 @default.
• W4382995874 hasConcept C62478195 @default.
• W4382995874 hasConcept C81885089 @default.
• W4382995874 hasConcept C86803240 @default.
• W4382995874 hasConcept C95444343 @default.
• W4382995874 hasConceptScore W4382995874C104317684 @default.
• W4382995874 hasConceptScore W4382995874C119056186 @default.
• W4382995874 hasConceptScore W4382995874C1491633281 @default.
• W4382995874 hasConceptScore W4382995874C173396325 @default.
• W4382995874 hasConceptScore W4382995874C2778729363 @default.
• W4382995874 hasConceptScore W4382995874C29537977 @default.
• W4382995874 hasConceptScore W4382995874C502942594 @default.
• W4382995874 hasConceptScore W4382995874C54355233 @default.
• W4382995874 hasConceptScore W4382995874C55493867 @default.
• W4382995874 hasConceptScore W4382995874C57074206 @default.
• W4382995874 hasConceptScore W4382995874C62112901 @default.
• W4382995874 hasConceptScore W4382995874C62478195 @default.
• W4382995874 hasConceptScore W4382995874C81885089 @default.
• W4382995874 hasConceptScore W4382995874C86803240 @default.
• W4382995874 hasConceptScore W4382995874C95444343 @default.
• W4382995874 hasIssue "4" @default.
• W4382995874 hasLocation W43829958741 @default.
• W4382995874 hasLocation W43829958742 @default.
• W4382995874 hasOpenAccess W4382995874 @default.
• W4382995874 hasPrimaryLocation W43829958741 @default.
• W4382995874 hasRelatedWork W2039201715 @default.
• W4382995874 hasRelatedWork W2054925689 @default.
• W4382995874 hasRelatedWork W2117441185 @default.
• W4382995874 hasRelatedWork W2377185255 @default.
• W4382995874 hasRelatedWork W2562103693 @default.
• W4382995874 hasRelatedWork W3094951633 @default.
• W4382995874 hasRelatedWork W3130220624 @default.
• W4382995874 hasRelatedWork W4280493527 @default.
• W4382995874 hasRelatedWork W4319923850 @default.
• W4382995874 hasRelatedWork W4383711253 @default.
• W4382995874 hasVolume "66" @default.
• W4382995874 isParatext "false" @default.
• W4382995874 isRetracted "false" @default.

• next