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- W4383040650 abstract "Abstract Excessive usage of antibiotics threatens the bacterial diversity in the microbiota of animals. An alternative to antibiotics that has been suggested to not disturb the microbiota is (bacterio)phage therapy. In this study, we challenged germ-free and microbially colonized yolk sac fry of Atlantic salmon with Flavobacterium columnare and observed that the mere presence of a microbiota protected the fish against lethal infection. We then investigated the effect of phage-or oxytetracycline treatment on fish survival and rearing water bacterial community characteristics using 16S rRNA gene amplicon sequencing. Phage treatment led to an increased survival of F. columnare- challenged fish and reduced the relative amounts of the pathogen in the water microbiota. In the absence of F. columnare , phage treatment did not affect the composition or the α-diversity of the rearing water microbiota. In the presence of the phage’s host, phage treatment induced minor changes to the bacterial community composition, without affecting the α-diversity. Surprisingly, oxytetracycline treatment had no observable effect on the water microbiota and did not reduce the relative abundance of F. columnare in the water. In conclusion, we showed that phage treatment prevents mortality while not negatively affecting the rearing water microbiota, thus suggesting that phage treatment may be a suitable alternative to antibiotics. We also demonstrated a protective effect of the microbiota in Atlantic salmon yolk sac fry." @default.
- W4383040650 created "2023-07-04" @default.
- W4383040650 creator A5003678652 @default.
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- W4383040650 date "2023-07-04" @default.
- W4383040650 modified "2023-09-25" @default.
- W4383040650 title "Phage therapy minimally affects the water microbiota in an Atlantic salmon (<i>Salmo salar</i>) rearing system while still preventing infection" @default.
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- W4383040650 doi "https://doi.org/10.1101/2023.07.03.547070" @default.
- W4383040650 hasPublicationYear "2023" @default.
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