FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383058999> ?p ?o ?g. }

• W4383058999 endingPage "3665" @default.
• W4383058999 startingPage "3649" @default.
• W4383058999 abstract "Abstract As an epitranscriptomic modulation manner, N 6 ‐methyladenosine (m 6 A) modification plays important roles in various diseases, including hepatocellular carcinoma (HCC). m 6 A modification affects the fate of RNAs. The potential contributions of m 6 A to the functions of RNA still need further investigation. In this study, we identified long noncoding RNA FAM111A‐DT as an m 6 A‐modified RNA and confirmed three m 6 A sites on FAM111A‐DT. The m 6 A modification level of FAM111A‐DT was increased in HCC tissues and cell lines, and increased m 6 A level was correlated with poor survival of HCC patients. m 6 A modification increased the stability of FAM111A‐DT transcript, whose expression level showed similar clinical relevance to that of the m 6 A level of FAM111A‐DT. Functional assays found that only m 6 A‐modified FAM111A‐DT promoted HCC cellular proliferation, DNA replication, and HCC tumor growth. Mutation of m 6 A sites on FAM111A‐DT abolished the roles of FAM111A‐DT. Mechanistic investigations found that m 6 A‐modified FAM111A‐DT bound to FAM111A promoter and also interacted with m 6 A reader YTHDC1, which further bound and recruited histone demethylase KDM3B to FAM111A promoter, leading to the reduction of the repressive histone mark H3K9me2 and transcriptional activation of FAM111A . The expression of FAM111A was positively correlated with the m 6 A level of FAM111A‐DT, and the expression of methyltransferase complex, YTHDC1, and KDM3B in HCC tissues. Depletion of FAM111A largely attenuated the roles of m 6 A‐modified FAM111A‐DT in HCC. In summary, the m 6 A‐modified FAM111A‐DT/YTHDC1/KDM3B/FAM111A regulatory axis promoted HCC growth and represented a candidate therapeutic target for HCC." @default.
• W4383058999 created "2023-07-05" @default.
• W4383058999 creator A5001130465 @default.
• W4383058999 creator A5023744469 @default.
• W4383058999 creator A5023979291 @default.
• W4383058999 creator A5044012938 @default.
• W4383058999 creator A5054466018 @default.
• W4383058999 creator A5062665531 @default.
• W4383058999 creator A5062878144 @default.
• W4383058999 creator A5063281508 @default.
• W4383058999 creator A5066986885 @default.
• W4383058999 creator A5080811040 @default.
• W4383058999 creator A5082818660 @default.
• W4383058999 creator A5090306049 @default.
• W4383058999 date "2023-07-03" @default.
• W4383058999 modified "2023-10-11" @default.
• W4383058999 title "<scp>N⁶</scp>‐methyladenosine‐modified <scp>FAM111A‐DT</scp> promotes hepatocellular carcinoma growth via epigenetically activating <scp>FAM111A</scp>" @default.
• W4383058999 cites W2002060172 @default.
• W4383058999 cites W2018851752 @default.
• W4383058999 cites W2057130382 @default.
• W4383058999 cites W2068517905 @default.
• W4383058999 cites W2071168599 @default.
• W4383058999 cites W2082496440 @default.
• W4383058999 cites W2146784968 @default.
• W4383058999 cites W2167226090 @default.
• W4383058999 cites W2287984595 @default.
• W4383058999 cites W2324488473 @default.
• W4383058999 cites W2508545091 @default.
• W4383058999 cites W2601868035 @default.
• W4383058999 cites W2618859545 @default.
• W4383058999 cites W2667527464 @default.
• W4383058999 cites W2729868770 @default.
• W4383058999 cites W2762279748 @default.
• W4383058999 cites W2804442559 @default.
• W4383058999 cites W2897520171 @default.
• W4383058999 cites W2902488470 @default.
• W4383058999 cites W2995376737 @default.
• W4383058999 cites W3011781484 @default.
• W4383058999 cites W3048054690 @default.
• W4383058999 cites W3049406555 @default.
• W4383058999 cites W3095882490 @default.
• W4383058999 cites W3138433399 @default.
• W4383058999 cites W3157951405 @default.
• W4383058999 cites W3159311544 @default.
• W4383058999 cites W3162105687 @default.
• W4383058999 cites W3164912031 @default.
• W4383058999 cites W3165132368 @default.
• W4383058999 cites W3183616390 @default.
• W4383058999 cites W3207010619 @default.
• W4383058999 cites W3215459266 @default.
• W4383058999 cites W4210395777 @default.
• W4383058999 cites W4212828605 @default.
• W4383058999 cites W4214809085 @default.
• W4383058999 cites W4220799240 @default.
• W4383058999 cites W4221122792 @default.
• W4383058999 cites W4225276726 @default.
• W4383058999 cites W4232620598 @default.
• W4383058999 cites W4281249481 @default.
• W4383058999 cites W4281297277 @default.
• W4383058999 cites W4281732514 @default.
• W4383058999 cites W4283024773 @default.
• W4383058999 cites W4287510049 @default.
• W4383058999 cites W4289783269 @default.
• W4383058999 cites W4291020351 @default.
• W4383058999 cites W4293088886 @default.
• W4383058999 cites W4294904827 @default.
• W4383058999 cites W4296794785 @default.
• W4383058999 cites W4296795237 @default.
• W4383058999 cites W4306786775 @default.
• W4383058999 cites W4306925964 @default.
• W4383058999 cites W4307447022 @default.
• W4383058999 cites W4310871679 @default.
• W4383058999 cites W4311612990 @default.
• W4383058999 cites W4317501234 @default.
• W4383058999 cites W4383058999 @default.
• W4383058999 doi "https://doi.org/10.1111/cas.15886" @default.
• W4383058999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37400994" @default.
• W4383058999 hasPublicationYear "2023" @default.
• W4383058999 type Work @default.
• W4383058999 citedByCount "1" @default.
• W4383058999 countsByYear W43830589992023 @default.
• W4383058999 crossrefType "journal-article" @default.
• W4383058999 hasAuthorship W4383058999A5001130465 @default.
• W4383058999 hasAuthorship W4383058999A5023744469 @default.
• W4383058999 hasAuthorship W4383058999A5023979291 @default.
• W4383058999 hasAuthorship W4383058999A5044012938 @default.
• W4383058999 hasAuthorship W4383058999A5054466018 @default.
• W4383058999 hasAuthorship W4383058999A5062665531 @default.
• W4383058999 hasAuthorship W4383058999A5062878144 @default.
• W4383058999 hasAuthorship W4383058999A5063281508 @default.
• W4383058999 hasAuthorship W4383058999A5066986885 @default.
• W4383058999 hasAuthorship W4383058999A5080811040 @default.
• W4383058999 hasAuthorship W4383058999A5082818660 @default.
• W4383058999 hasAuthorship W4383058999A5090306049 @default.
• W4383058999 hasBestOaLocation W43830589991 @default.
• W4383058999 hasConcept C104317684 @default.
• W4383058999 hasConcept C153911025 @default.
• W4383058999 hasConcept C166703698 @default.

• next