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• W4383059178 abstract "Abstract In female mammals, the oviduct and uterus are essential sites for female and male gamete transport, fertilization, implantation, and maintenance of a successful pregnancy. To delineate the reproductive function of Mothers against decapentaplegic homolog 4 ( Smad4 ), we specifically inactivated Smad4 in ovarian granulosa cells and, oviduct and uterine mesenchymal cells using the Amhr2 ‐ cre mouse line. Deletion of exon 8 of Smad4 results in the production of an MH2‐truncated SMAD4 protein. These mutant mice are infertile due to the development of oviductal diverticula and defects during the implantation process. The ovaries are fully functional as demonstrated in an ovary transfer experiment. The development of oviductal diverticula occurs shortly after puberty and is dependent on estradiol. The diverticula interfere with sperm migration and embryo transit to the uterus, reducing the number of implantation sites. Analysis of the uterus shows that, even if implantation occurs, decidualization and vascularization are defective resulting in embryo resorption as early as the seventh day of pregnancy. Thus, Smad4 plays an important function in female reproduction by controlling the structural and functional integrity of the oviduct and uterus." @default.
• W4383059178 created "2023-07-05" @default.
• W4383059178 creator A5010280433 @default.
• W4383059178 creator A5015996736 @default.
• W4383059178 creator A5024857844 @default.
• W4383059178 creator A5050911555 @default.
• W4383059178 creator A5065222729 @default.
• W4383059178 creator A5065415365 @default.
• W4383059178 creator A5073396552 @default.
• W4383059178 date "2023-07-04" @default.
• W4383059178 modified "2023-10-18" @default.
• W4383059178 title "Uterine defects and estradiol‐dependent development of oviductal diverticula in mice lacking the <scp>SMAD4</scp> C‐terminal Mad homology 2 domain" @default.
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