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• W4383070049 abstract "Abstract Overeating is driven by both the hedonic component (‘liking’) of food, and the motivation (‘wanting’) to eat it. The nucleus accumbens (NAc) is a key brain center implicated in these processes, but how distinct NAc cell populations encode ‘liking’ and ‘wanting’ to shape overconsumption remains unclear. Here, we probed the roles of NAc D1 and D2 cells in these processes using cell-specific recording and optogenetic manipulation in diverse behavioral paradigms that disentangle reward traits of ‘liking’ and ‘wanting’ related to food choice and overeating in healthy mice. Medial NAc shell D2 cells encoded experience-dependent development of ‘liking’, while D1 cells encoded innate ‘liking’ during the first food taste. Optogenetic control confirmed causal links of D1 and D2 cells to these aspects of ‘liking’. In relation to ‘wanting’, D1 and D2 cells encoded and promoted distinct aspects of food approach: D1 cells interpreted food cues while D2 cells also sustained food-visit-length that facilitates consumption. Finally, at the level of food choice, D1, but not D2, cell activity was sufficient to switch food preference, programming subsequent long-lasting overconsumption. By revealing complementary roles of D1 and D2 cells in consumption, these findings assign neural bases to ‘liking’ and ‘wanting’ in a unifying framework of D1 and D2 cell activity." @default.
• W4383070049 created "2023-07-05" @default.
• W4383070049 creator A5002023120 @default.
• W4383070049 creator A5020410533 @default.
• W4383070049 creator A5031535677 @default.
• W4383070049 creator A5058990653 @default.
• W4383070049 creator A5070613845 @default.
• W4383070049 date "2023-07-04" @default.
• W4383070049 modified "2023-10-16" @default.
• W4383070049 title "Disentangling the role of NAc D1 and D2 cells in hedonic eating" @default.
• W4383070049 cites W1969292536 @default.
• W4383070049 cites W1969401266 @default.
• W4383070049 cites W1976178756 @default.
• W4383070049 cites W1976544983 @default.
• W4383070049 cites W1976844911 @default.
• W4383070049 cites W1977266070 @default.
• W4383070049 cites W1977658700 @default.
• W4383070049 cites W1978269098 @default.
• W4383070049 cites W1980929078 @default.
• W4383070049 cites W1989416066 @default.
• W4383070049 cites W1993305928 @default.
• W4383070049 cites W1996812852 @default.
• W4383070049 cites W1996883125 @default.
• W4383070049 cites W1997732184 @default.
• W4383070049 cites W1999592924 @default.
• W4383070049 cites W2003569865 @default.
• W4383070049 cites W2003982930 @default.
• W4383070049 cites W2006780016 @default.
• W4383070049 cites W2007910638 @default.
• W4383070049 cites W2009295793 @default.
• W4383070049 cites W2011275122 @default.
• W4383070049 cites W2016362864 @default.
• W4383070049 cites W2017475292 @default.
• W4383070049 cites W2021782736 @default.
• W4383070049 cites W2022633426 @default.
• W4383070049 cites W2023972158 @default.
• W4383070049 cites W2024320834 @default.
• W4383070049 cites W2026308087 @default.
• W4383070049 cites W2027884774 @default.
• W4383070049 cites W2033594624 @default.
• W4383070049 cites W2034331584 @default.
• W4383070049 cites W2035068403 @default.
• W4383070049 cites W2035532999 @default.
• W4383070049 cites W2035744158 @default.
• W4383070049 cites W2045967877 @default.
• W4383070049 cites W2046739058 @default.
• W4383070049 cites W2049326672 @default.
• W4383070049 cites W2050518055 @default.
• W4383070049 cites W2052010991 @default.
• W4383070049 cites W2052366277 @default.
• W4383070049 cites W2069600955 @default.
• W4383070049 cites W2070465295 @default.
• W4383070049 cites W2074382500 @default.
• W4383070049 cites W2077523950 @default.
• W4383070049 cites W2079590230 @default.
• W4383070049 cites W2079756607 @default.
• W4383070049 cites W2080664107 @default.
• W4383070049 cites W2083270036 @default.
• W4383070049 cites W2085293745 @default.
• W4383070049 cites W2085685449 @default.
• W4383070049 cites W2085782088 @default.
• W4383070049 cites W2088429095 @default.
• W4383070049 cites W2094157831 @default.
• W4383070049 cites W2095219741 @default.
• W4383070049 cites W2098766452 @default.
• W4383070049 cites W2106862702 @default.
• W4383070049 cites W2107440671 @default.
• W4383070049 cites W2109059823 @default.
• W4383070049 cites W2114207481 @default.
• W4383070049 cites W2114586089 @default.
• W4383070049 cites W2126104034 @default.
• W4383070049 cites W2127946577 @default.
• W4383070049 cites W2138724749 @default.
• W4383070049 cites W2141376829 @default.
• W4383070049 cites W2141794225 @default.
• W4383070049 cites W2147042533 @default.
• W4383070049 cites W2147639837 @default.
• W4383070049 cites W2151211427 @default.
• W4383070049 cites W2157844171 @default.
• W4383070049 cites W2157849519 @default.
• W4383070049 cites W2163773342 @default.
• W4383070049 cites W2164060165 @default.
• W4383070049 cites W2164656906 @default.
• W4383070049 cites W2167999147 @default.
• W4383070049 cites W2170276695 @default.
• W4383070049 cites W2171521575 @default.
• W4383070049 cites W2173939482 @default.
• W4383070049 cites W2174764226 @default.
• W4383070049 cites W2178079081 @default.
• W4383070049 cites W2191212968 @default.
• W4383070049 cites W2269023483 @default.
• W4383070049 cites W2316293321 @default.
• W4383070049 cites W2317485149 @default.
• W4383070049 cites W2318849400 @default.
• W4383070049 cites W2336259232 @default.
• W4383070049 cites W2408526765 @default.
• W4383070049 cites W2462952368 @default.
• W4383070049 cites W2466169662 @default.
• W4383070049 cites W2509244163 @default.
• W4383070049 cites W2556131729 @default.

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