Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383070136> ?p ?o ?g. }
- W4383070136 abstract "Aging results in a decline of cellular proteostasis capacity which culminates in the accumulation of phototoxic material, causing the onset of age-related maladies and ultimately cell death. Mechanisms that regulate proteostasis such as cellular stress response pathways sense disturbances in the proteome. They are activated to increase the expression of protein quality control components that counteract cellular damage. Utilizing invertebrate model organisms such as Caenorhabditis elegans , it has become increasingly evident that the regulation of proteostasis and the activation of cellular stress responses is not a cell autonomous process. In animals, stress responses are orchestrated by signals coming from other tissues, including the nervous system, the intestine and the germline that have a profound impact on determining the aging process. Genetic pathways discovered in C. elegans that facilitate cell nonautonomous regulation of stress responses are providing an exciting feeding ground for new interventions. In this review I will discuss cell nonautonomous proteostasis mechanisms and their impact on aging as well as ongoing research and clinical trials that can increase organismal proteostasis to lengthen health- and lifespan." @default.
- W4383070136 created "2023-07-05" @default.
- W4383070136 creator A5087275613 @default.
- W4383070136 date "2023-07-04" @default.
- W4383070136 modified "2023-10-17" @default.
- W4383070136 title "Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging" @default.
- W4383070136 cites W1500828543 @default.
- W4383070136 cites W1619158228 @default.
- W4383070136 cites W1847809821 @default.
- W4383070136 cites W1857695392 @default.
- W4383070136 cites W1948999853 @default.
- W4383070136 cites W1963954263 @default.
- W4383070136 cites W1965580206 @default.
- W4383070136 cites W1965588810 @default.
- W4383070136 cites W1972745320 @default.
- W4383070136 cites W1977603207 @default.
- W4383070136 cites W1979344081 @default.
- W4383070136 cites W1982035848 @default.
- W4383070136 cites W1982164848 @default.
- W4383070136 cites W1982376676 @default.
- W4383070136 cites W1986172762 @default.
- W4383070136 cites W1994305081 @default.
- W4383070136 cites W1994486588 @default.
- W4383070136 cites W1994519704 @default.
- W4383070136 cites W1995011388 @default.
- W4383070136 cites W1996509853 @default.
- W4383070136 cites W2001908075 @default.
- W4383070136 cites W2010181168 @default.
- W4383070136 cites W2011277283 @default.
- W4383070136 cites W2014287442 @default.
- W4383070136 cites W2017778853 @default.
- W4383070136 cites W2020240443 @default.
- W4383070136 cites W2020335617 @default.
- W4383070136 cites W2023402149 @default.
- W4383070136 cites W2023431124 @default.
- W4383070136 cites W2025851491 @default.
- W4383070136 cites W2029639109 @default.
- W4383070136 cites W2032306298 @default.
- W4383070136 cites W2036310769 @default.
- W4383070136 cites W2037911961 @default.
- W4383070136 cites W2038279476 @default.
- W4383070136 cites W2046753623 @default.
- W4383070136 cites W2046989794 @default.
- W4383070136 cites W2047516613 @default.
- W4383070136 cites W2048967691 @default.
- W4383070136 cites W2057714995 @default.
- W4383070136 cites W2059524588 @default.
- W4383070136 cites W2073841074 @default.
- W4383070136 cites W2084211225 @default.
- W4383070136 cites W2084614729 @default.
- W4383070136 cites W2085089053 @default.
- W4383070136 cites W2095250167 @default.
- W4383070136 cites W2098953186 @default.
- W4383070136 cites W2102824402 @default.
- W4383070136 cites W2103856526 @default.
- W4383070136 cites W2104199954 @default.
- W4383070136 cites W2109502717 @default.
- W4383070136 cites W2111822899 @default.
- W4383070136 cites W2115527176 @default.
- W4383070136 cites W2115971557 @default.
- W4383070136 cites W2130016073 @default.
- W4383070136 cites W2140197221 @default.
- W4383070136 cites W2140400644 @default.
- W4383070136 cites W2141444248 @default.
- W4383070136 cites W2148581106 @default.
- W4383070136 cites W2151160060 @default.
- W4383070136 cites W2151893314 @default.
- W4383070136 cites W2152217159 @default.
- W4383070136 cites W2152839556 @default.
- W4383070136 cites W2153459905 @default.
- W4383070136 cites W2164361361 @default.
- W4383070136 cites W2167235559 @default.
- W4383070136 cites W2214677303 @default.
- W4383070136 cites W2422981416 @default.
- W4383070136 cites W2426241773 @default.
- W4383070136 cites W2469581134 @default.
- W4383070136 cites W2474866772 @default.
- W4383070136 cites W2510841419 @default.
- W4383070136 cites W2551516228 @default.
- W4383070136 cites W2558713280 @default.
- W4383070136 cites W2601257457 @default.
- W4383070136 cites W2606824156 @default.
- W4383070136 cites W2613911880 @default.
- W4383070136 cites W2624386673 @default.
- W4383070136 cites W2761106977 @default.
- W4383070136 cites W2765873986 @default.
- W4383070136 cites W2770372563 @default.
- W4383070136 cites W2784241249 @default.
- W4383070136 cites W2793430158 @default.
- W4383070136 cites W2810557289 @default.
- W4383070136 cites W2883028445 @default.
- W4383070136 cites W2886305647 @default.
- W4383070136 cites W2901930262 @default.
- W4383070136 cites W2908986552 @default.
- W4383070136 cites W2913172834 @default.
- W4383070136 cites W2913687928 @default.
- W4383070136 cites W2960480621 @default.
- W4383070136 cites W2962598558 @default.
- W4383070136 cites W2968831837 @default.
- W4383070136 cites W2975586507 @default.