Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383163629> ?p ?o ?g. }
- W4383163629 endingPage "110573" @default.
- W4383163629 startingPage "110573" @default.
- W4383163629 abstract "Beta-lactam (BLM) antibiotics, including amino-penicillin and cephalosporins, are typically the first-choice treatment for bacterial infections. However, adverse reactions to these antibiotics are frequently reported, causing non-allergist physicians to select alternative broad-spectrum antibiotics that can have harmful consequences. Patients with unclear histories of hypersensitivity reactions to BLMs should undergo an allergy workup to establish a firm diagnosis, particularly when different drugs are prescribed simultaneously. However, finding the safest, most precise, and cost-effective methods for confirming BLMs hypersensitivity and selecting the most appropriate alternative BLM is uncertain, particularly in severe delayed reactions. This review aims to provide data and recommendations on the availability and validity of skin tests (STs), drug provocation test (DPT) protocols, based on the latest published literature and guideline. To make the process more practical, we focused on cross-reactivity between BLMs and diagnostic tests. There are two main novel aspects of this document: 1) For T-cell-mediated reactions, patient stratification into high, moderate, and low-risk groups based on the mortality and morbidity of adverse drug reactions. 2) For IgE-mediated reactions, stratification of individuals with isolated limited urticarial without anaphylaxis in a low-risk group and removal of the extensive limitation." @default.
- W4383163629 created "2023-07-05" @default.
- W4383163629 creator A5001558305 @default.
- W4383163629 creator A5005999912 @default.
- W4383163629 creator A5022184297 @default.
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- W4383163629 creator A5032000014 @default.
- W4383163629 creator A5052123635 @default.
- W4383163629 creator A5076269679 @default.
- W4383163629 date "2023-09-01" @default.
- W4383163629 modified "2023-10-06" @default.
- W4383163629 title "Diagnosis and selection of alternative antibiotics in beta-lactams hypersensitivity reactions: Current recommendations and challenges" @default.
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