FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383186824> ?p ?o ?g. }

• W4383186824 endingPage "274" @default.
• W4383186824 startingPage "249" @default.
• W4383186824 abstract "The binding pocket of some therapeutic targets can acquire multiple conformations that, to some extent, depend on the protein dynamics and the interaction with other molecules. The inability to reach the binding pocket can impose a substantial or even insurmountable barrier for the de novo identification or optimization of small-molecule ligands. Herein, we describe a protocol for the engineering of a target protein and a yeast displayYeast display FACSFluorescence-activated cell sorting (FACS) sorting strategy to identify protein variants with a stable transient binding pocketTransient binding pockets with improved binding for a cryptic site-specific ligand. This strategy may facilitate drug discovery using the resulting protein variants with accessible binding pockets for ligand screening." @default.
• W4383186824 created "2023-07-06" @default.
• W4383186824 creator A5052655402 @default.
• W4383186824 creator A5061848625 @default.
• W4383186824 date "2023-01-01" @default.
• W4383186824 modified "2023-10-01" @default.
• W4383186824 title "Accessing Transient Binding Pockets by Protein Engineering and Yeast Surface Display Screening" @default.
• W4383186824 cites W141181845 @default.
• W4383186824 cites W1571577887 @default.
• W4383186824 cites W1965451896 @default.
• W4383186824 cites W1974645077 @default.
• W4383186824 cites W1991518694 @default.
• W4383186824 cites W1999195584 @default.
• W4383186824 cites W2002440238 @default.
• W4383186824 cites W2004126244 @default.
• W4383186824 cites W2009007740 @default.
• W4383186824 cites W2009358092 @default.
• W4383186824 cites W2023470556 @default.
• W4383186824 cites W2061090993 @default.
• W4383186824 cites W2066672837 @default.
• W4383186824 cites W2079493278 @default.
• W4383186824 cites W2096454260 @default.
• W4383186824 cites W2103994532 @default.
• W4383186824 cites W2107409328 @default.
• W4383186824 cites W2118571345 @default.
• W4383186824 cites W2123529526 @default.
• W4383186824 cites W2320259278 @default.
• W4383186824 cites W2343614482 @default.
• W4383186824 cites W2467283743 @default.
• W4383186824 cites W2530847795 @default.
• W4383186824 cites W2791506886 @default.
• W4383186824 cites W2981227980 @default.
• W4383186824 cites W3125347272 @default.
• W4383186824 cites W4214840794 @default.
• W4383186824 cites W4308477149 @default.
• W4383186824 doi "https://doi.org/10.1007/978-1-0716-3279-6_14" @default.
• W4383186824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37405652" @default.
• W4383186824 hasPublicationYear "2023" @default.
• W4383186824 type Work @default.
• W4383186824 citedByCount "0" @default.
• W4383186824 crossrefType "book-chapter" @default.
• W4383186824 hasAuthorship W4383186824A5052655402 @default.
• W4383186824 hasAuthorship W4383186824A5061848625 @default.
• W4383186824 hasConcept C104317684 @default.
• W4383186824 hasConcept C107824862 @default.
• W4383186824 hasConcept C116569031 @default.
• W4383186824 hasConcept C147816474 @default.
• W4383186824 hasConcept C1491633281 @default.
• W4383186824 hasConcept C159047783 @default.
• W4383186824 hasConcept C161624437 @default.
• W4383186824 hasConcept C170493617 @default.
• W4383186824 hasConcept C181199279 @default.
• W4383186824 hasConcept C185592680 @default.
• W4383186824 hasConcept C2778630268 @default.
• W4383186824 hasConcept C2779222958 @default.
• W4383186824 hasConcept C2780430158 @default.
• W4383186824 hasConcept C3019232848 @default.
• W4383186824 hasConcept C3020299119 @default.
• W4383186824 hasConcept C51639874 @default.
• W4383186824 hasConcept C55493867 @default.
• W4383186824 hasConcept C70721500 @default.
• W4383186824 hasConcept C74187038 @default.
• W4383186824 hasConcept C86803240 @default.
• W4383186824 hasConcept C95444343 @default.
• W4383186824 hasConceptScore W4383186824C104317684 @default.
• W4383186824 hasConceptScore W4383186824C107824862 @default.
• W4383186824 hasConceptScore W4383186824C116569031 @default.
• W4383186824 hasConceptScore W4383186824C147816474 @default.
• W4383186824 hasConceptScore W4383186824C1491633281 @default.
• W4383186824 hasConceptScore W4383186824C159047783 @default.
• W4383186824 hasConceptScore W4383186824C161624437 @default.
• W4383186824 hasConceptScore W4383186824C170493617 @default.
• W4383186824 hasConceptScore W4383186824C181199279 @default.
• W4383186824 hasConceptScore W4383186824C185592680 @default.
• W4383186824 hasConceptScore W4383186824C2778630268 @default.
• W4383186824 hasConceptScore W4383186824C2779222958 @default.
• W4383186824 hasConceptScore W4383186824C2780430158 @default.
• W4383186824 hasConceptScore W4383186824C3019232848 @default.
• W4383186824 hasConceptScore W4383186824C3020299119 @default.
• W4383186824 hasConceptScore W4383186824C51639874 @default.
• W4383186824 hasConceptScore W4383186824C55493867 @default.
• W4383186824 hasConceptScore W4383186824C70721500 @default.
• W4383186824 hasConceptScore W4383186824C74187038 @default.
• W4383186824 hasConceptScore W4383186824C86803240 @default.
• W4383186824 hasConceptScore W4383186824C95444343 @default.
• W4383186824 hasLocation W43831868241 @default.
• W4383186824 hasLocation W43831868242 @default.
• W4383186824 hasOpenAccess W4383186824 @default.
• W4383186824 hasPrimaryLocation W43831868241 @default.
• W4383186824 hasRelatedWork W2050880666 @default.
• W4383186824 hasRelatedWork W2054118966 @default.
• W4383186824 hasRelatedWork W2073746700 @default.
• W4383186824 hasRelatedWork W2128991310 @default.
• W4383186824 hasRelatedWork W2301371353 @default.
• W4383186824 hasRelatedWork W2559132852 @default.
• W4383186824 hasRelatedWork W2605573491 @default.
• W4383186824 hasRelatedWork W4281692789 @default.
• W4383186824 hasRelatedWork W4383186824 @default.

• next