Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383198718> ?p ?o ?g. }
- W4383198718 endingPage "e1010795" @default.
- W4383198718 startingPage "e1010795" @default.
- W4383198718 abstract "Retrotransposons have generated about half of the human genome and LINE-1s (L1s) are the only autonomously active retrotransposons. The cell has evolved an arsenal of defense mechanisms to protect against retrotransposition with factors we are only beginning to understand. In this study, we investigate Zinc Finger CCHC-Type Containing 3 (ZCCHC3), a gag-like zinc knuckle protein recently reported to function in the innate immune response to infecting viruses. We show that ZCCHC3 also severely restricts human retrotransposons and associates with the L1 ORF1p ribonucleoprotein particle. We identify ZCCHC3 as a bona fide stress granule protein, and its association with LINE-1 is further supported by colocalization with L1 ORF1 protein in stress granules, dense cytoplasmic aggregations of proteins and RNAs that contain stalled translation pre-initiation complexes and form when the cell is under stress. Our work also draws links between ZCCHC3 and the anti-viral and retrotransposon restriction factors Mov10 RISC Complex RNA Helicase (MOV10) and Zinc Finger CCCH-Type, Antiviral 1 (ZC3HAV1, also called ZAP). Furthermore, collective evidence from subcellular localization, co-immunoprecipitation, and velocity gradient centrifugation connects ZCCHC3 with the RNA exosome, a multi-subunit ribonuclease complex capable of degrading various species of RNA molecules and that has previously been linked with retrotransposon control." @default.
- W4383198718 created "2023-07-06" @default.
- W4383198718 creator A5019524405 @default.
- W4383198718 creator A5023768954 @default.
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- W4383198718 creator A5080411990 @default.
- W4383198718 creator A5082065635 @default.
- W4383198718 creator A5092402412 @default.
- W4383198718 date "2023-07-05" @default.
- W4383198718 modified "2023-09-27" @default.
- W4383198718 title "ZCCHC3 is a stress granule zinc knuckle protein that strongly suppresses LINE-1 retrotransposition" @default.
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