FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383216428> ?p ?o ?g. }

• W4383216428 abstract "Abstract Protein dynamics play a crucial role in their diverse functions. The intracellular environment significantly influences protein dynamics, particularly for intrinsically disordered proteins (IDPs). To comprehensively capture structural information from various proteins within cells and characterize protein dynamics, chemical cross‐linking mass spectrometry was employed. In this study, we introduce a hierarchical decoding strategy that enables the investigation of protein dynamics in vivo. Computational analysis based on distance restraints derived from cross‐links is used to infer protein dynamics in cells. To facilitate this analysis, we leverage the prior structure obtained from AlphaFold2. By employing this strategy, we can characterize the full‐length structure of multi‐domain proteins taking into account their distinct dynamic features. Furthermore, by combining restraint sampling with an unbiased sampling and evaluation approach, we can provide a comprehensive description of the intrinsic motion of IDPs. Consequently, the hierarchical strategy we propose holds significant potential in advancing our understanding of the molecular mechanisms that undelie protein functions in cells." @default.
• W4383216428 created "2023-07-06" @default.
• W4383216428 creator A5011512354 @default.
• W4383216428 creator A5014169110 @default.
• W4383216428 creator A5014872169 @default.
• W4383216428 creator A5016279721 @default.
• W4383216428 creator A5029688919 @default.
• W4383216428 creator A5037275451 @default.
• W4383216428 creator A5048379858 @default.
• W4383216428 creator A5049365368 @default.
• W4383216428 creator A5060264631 @default.
• W4383216428 creator A5060842938 @default.
• W4383216428 creator A5083455182 @default.
• W4383216428 date "2023-07-20" @default.
• W4383216428 modified "2023-10-17" @default.
• W4383216428 title "Decoding Protein Dynamics in Cells Using Chemical Cross‐Linking and Hierarchical Analysis**" @default.
• W4383216428 cites W1921676712 @default.
• W4383216428 cites W1977504093 @default.
• W4383216428 cites W2008487411 @default.
• W4383216428 cites W2017284082 @default.
• W4383216428 cites W2021017943 @default.
• W4383216428 cites W2040370905 @default.
• W4383216428 cites W2076710572 @default.
• W4383216428 cites W2088566989 @default.
• W4383216428 cites W2111312305 @default.
• W4383216428 cites W2122536893 @default.
• W4383216428 cites W2400154544 @default.
• W4383216428 cites W2518861643 @default.
• W4383216428 cites W2519691041 @default.
• W4383216428 cites W2564528384 @default.
• W4383216428 cites W2794305966 @default.
• W4383216428 cites W2800057751 @default.
• W4383216428 cites W2888881600 @default.
• W4383216428 cites W2896816499 @default.
• W4383216428 cites W2999044305 @default.
• W4383216428 cites W3153594869 @default.
• W4383216428 cites W3177828909 @default.
• W4383216428 cites W3183475563 @default.
• W4383216428 cites W3195375135 @default.
• W4383216428 cites W4212922451 @default.
• W4383216428 cites W4224214254 @default.
• W4383216428 cites W4224259818 @default.
• W4383216428 cites W4280522303 @default.
• W4383216428 cites W4280548378 @default.
• W4383216428 cites W4309737920 @default.
• W4383216428 cites W4321596020 @default.
• W4383216428 cites W4328048207 @default.
• W4383216428 cites W4366239170 @default.
• W4383216428 doi "https://doi.org/10.1002/ange.202301345" @default.
• W4383216428 hasPublicationYear "2023" @default.
• W4383216428 type Work @default.
• W4383216428 citedByCount "0" @default.
• W4383216428 crossrefType "journal-article" @default.
• W4383216428 hasAuthorship W4383216428A5011512354 @default.
• W4383216428 hasAuthorship W4383216428A5014169110 @default.
• W4383216428 hasAuthorship W4383216428A5014872169 @default.
• W4383216428 hasAuthorship W4383216428A5016279721 @default.
• W4383216428 hasAuthorship W4383216428A5029688919 @default.
• W4383216428 hasAuthorship W4383216428A5037275451 @default.
• W4383216428 hasAuthorship W4383216428A5048379858 @default.
• W4383216428 hasAuthorship W4383216428A5049365368 @default.
• W4383216428 hasAuthorship W4383216428A5060264631 @default.
• W4383216428 hasAuthorship W4383216428A5060842938 @default.
• W4383216428 hasAuthorship W4383216428A5083455182 @default.
• W4383216428 hasConcept C104317684 @default.
• W4383216428 hasConcept C11413529 @default.
• W4383216428 hasConcept C121332964 @default.
• W4383216428 hasConcept C12554922 @default.
• W4383216428 hasConcept C144292202 @default.
• W4383216428 hasConcept C145912823 @default.
• W4383216428 hasConcept C147597530 @default.
• W4383216428 hasConcept C153083717 @default.
• W4383216428 hasConcept C154945302 @default.
• W4383216428 hasConcept C185592680 @default.
• W4383216428 hasConcept C186060115 @default.
• W4383216428 hasConcept C24890656 @default.
• W4383216428 hasConcept C2775981520 @default.
• W4383216428 hasConcept C2778815515 @default.
• W4383216428 hasConcept C41008148 @default.
• W4383216428 hasConcept C47701112 @default.
• W4383216428 hasConcept C55493867 @default.
• W4383216428 hasConcept C57273362 @default.
• W4383216428 hasConcept C59593255 @default.
• W4383216428 hasConcept C70721500 @default.
• W4383216428 hasConcept C86803240 @default.
• W4383216428 hasConceptScore W4383216428C104317684 @default.
• W4383216428 hasConceptScore W4383216428C11413529 @default.
• W4383216428 hasConceptScore W4383216428C121332964 @default.
• W4383216428 hasConceptScore W4383216428C12554922 @default.
• W4383216428 hasConceptScore W4383216428C144292202 @default.
• W4383216428 hasConceptScore W4383216428C145912823 @default.
• W4383216428 hasConceptScore W4383216428C147597530 @default.
• W4383216428 hasConceptScore W4383216428C153083717 @default.
• W4383216428 hasConceptScore W4383216428C154945302 @default.
• W4383216428 hasConceptScore W4383216428C185592680 @default.
• W4383216428 hasConceptScore W4383216428C186060115 @default.
• W4383216428 hasConceptScore W4383216428C24890656 @default.
• W4383216428 hasConceptScore W4383216428C2775981520 @default.
• W4383216428 hasConceptScore W4383216428C2778815515 @default.
• W4383216428 hasConceptScore W4383216428C41008148 @default.

• next