FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383216981> ?p ?o ?g. }

• W4383216981 abstract "Regional nodal status is one of the most powerful prognosticators in breast cancer. The sentinel lymph node biopsy (SLNB) evaluates the first node in the axillary lymphatic basin theorised to drain the anatomical region of breast cancer. Recent literature has appropriately raised the query of the need for SLNB for breast cancer in older patients (BCOP). Though some early-stage older patients may safely have SLNB omitted, we are potentially missing the under-represented aggressive cancers. No sentinel lymph node metastases nomogram has been developed solely from BCOP data to date. This study aimed to identify older patients with breast cancer at risk for nodal involvement using a nomogram developed from their data alone.A retrospective analysis of prospectively collected data on BCOP (aged ≥70 years) was performed using the Breast Surgery Quality Audit (BQA). Inclusion criteria were T1-2 invasive breast cancer patients that underwent a SLNB from 1st January 2001 to 31st December 2019. The primary outcome was nodal involvement. Data obtained from the dataset included: age, tumour type, tumour size in millimeters, histological grade, lymphovascular invasion, oestrogen receptor status, progesterone receptor status, HER2 status and referral source. Binary logistic regression was used to develop a nomogram. The model was internally validated by splitting the data set (80% for training and 20% for testing). A receiver operating characteristic curve was developed, with the area under the curve (AUC) and a calibration plot.There were 22,313 patients of which 14,856 (66.6%) were symptomatic presentations and 7457 (33.4%) were screen-detected. Invasive tumour type, tumour size, tumour grade, lymphovascular invasion, oestrogen receptors, and referral source indicated a statistically significant effect on predicting a nodal positivity event (Table 1). The AUC was 0.782 (95% CI 0.776-0.789) (Fig. 1a) and demonstrated good calibration (Fig. 1b). The negative predictive value established was 85%.We have developed an Australian sentinel lymph node metastasis nomogram for BCOP using routine histopathological data obtained pre-operatively (Fig. 2). This is the first Australian nomogram, as well as the first nomogram developed solely for BCOP - and maintains a superior AUC compared to other well-established nomograms." @default.
• W4383216981 created "2023-07-06" @default.
• W4383216981 creator A5035694546 @default.
• W4383216981 creator A5055049176 @default.
• W4383216981 creator A5085026301 @default.
• W4383216981 date "2023-07-01" @default.
• W4383216981 modified "2023-10-03" @default.
• W4383216981 title "An Australian-based nomogram predicting nodal positivity for breast cancer in older patients" @default.
• W4383216981 cites W1507969901 @default.
• W4383216981 cites W1994424239 @default.
• W4383216981 cites W2022585941 @default.
• W4383216981 cites W2074130447 @default.
• W4383216981 cites W2098641762 @default.
• W4383216981 cites W2122428334 @default.
• W4383216981 cites W2124966064 @default.
• W4383216981 cites W2133865595 @default.
• W4383216981 cites W2160986504 @default.
• W4383216981 cites W2203051527 @default.
• W4383216981 cites W2224729546 @default.
• W4383216981 cites W2614206447 @default.
• W4383216981 cites W2754855139 @default.
• W4383216981 cites W2768331682 @default.
• W4383216981 cites W2893602527 @default.
• W4383216981 cites W2918531572 @default.
• W4383216981 cites W2937269933 @default.
• W4383216981 cites W2981679558 @default.
• W4383216981 cites W3039436863 @default.
• W4383216981 cites W3110327263 @default.
• W4383216981 cites W3128192276 @default.
• W4383216981 cites W3133679434 @default.
• W4383216981 cites W3136401436 @default.
• W4383216981 cites W3145417893 @default.
• W4383216981 cites W3154240602 @default.
• W4383216981 cites W3173604836 @default.
• W4383216981 cites W3187181384 @default.
• W4383216981 cites W572930562 @default.
• W4383216981 doi "https://doi.org/10.1016/j.surge.2023.06.001" @default.
• W4383216981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37419764" @default.
• W4383216981 hasPublicationYear "2023" @default.
• W4383216981 type Work @default.
• W4383216981 citedByCount "0" @default.
• W4383216981 crossrefType "journal-article" @default.
• W4383216981 hasAuthorship W4383216981A5035694546 @default.
• W4383216981 hasAuthorship W4383216981A5055049176 @default.
• W4383216981 hasAuthorship W4383216981A5085026301 @default.
• W4383216981 hasConcept C121608353 @default.
• W4383216981 hasConcept C126322002 @default.
• W4383216981 hasConcept C126838900 @default.
• W4383216981 hasConcept C143998085 @default.
• W4383216981 hasConcept C146357865 @default.
• W4383216981 hasConcept C151730666 @default.
• W4383216981 hasConcept C179671157 @default.
• W4383216981 hasConcept C2778740770 @default.
• W4383216981 hasConcept C2779013556 @default.
• W4383216981 hasConcept C2780212769 @default.
• W4383216981 hasConcept C2780849966 @default.
• W4383216981 hasConcept C34626388 @default.
• W4383216981 hasConcept C530470458 @default.
• W4383216981 hasConcept C58471807 @default.
• W4383216981 hasConcept C71924100 @default.
• W4383216981 hasConcept C86803240 @default.
• W4383216981 hasConceptScore W4383216981C121608353 @default.
• W4383216981 hasConceptScore W4383216981C126322002 @default.
• W4383216981 hasConceptScore W4383216981C126838900 @default.
• W4383216981 hasConceptScore W4383216981C143998085 @default.
• W4383216981 hasConceptScore W4383216981C146357865 @default.
• W4383216981 hasConceptScore W4383216981C151730666 @default.
• W4383216981 hasConceptScore W4383216981C179671157 @default.
• W4383216981 hasConceptScore W4383216981C2778740770 @default.
• W4383216981 hasConceptScore W4383216981C2779013556 @default.
• W4383216981 hasConceptScore W4383216981C2780212769 @default.
• W4383216981 hasConceptScore W4383216981C2780849966 @default.
• W4383216981 hasConceptScore W4383216981C34626388 @default.
• W4383216981 hasConceptScore W4383216981C530470458 @default.
• W4383216981 hasConceptScore W4383216981C58471807 @default.
• W4383216981 hasConceptScore W4383216981C71924100 @default.
• W4383216981 hasConceptScore W4383216981C86803240 @default.
• W4383216981 hasLocation W43832169811 @default.
• W4383216981 hasLocation W43832169812 @default.
• W4383216981 hasOpenAccess W4383216981 @default.
• W4383216981 hasPrimaryLocation W43832169811 @default.
• W4383216981 hasRelatedWork W2007686878 @default.
• W4383216981 hasRelatedWork W2037404114 @default.
• W4383216981 hasRelatedWork W2072195749 @default.
• W4383216981 hasRelatedWork W2075616772 @default.
• W4383216981 hasRelatedWork W2160986504 @default.
• W4383216981 hasRelatedWork W2377488449 @default.
• W4383216981 hasRelatedWork W2559842760 @default.
• W4383216981 hasRelatedWork W3135167312 @default.
• W4383216981 hasRelatedWork W4256554205 @default.
• W4383216981 hasRelatedWork W4383216981 @default.
• W4383216981 isParatext "false" @default.
• W4383216981 isRetracted "false" @default.
• W4383216981 workType "article" @default.