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- W4383217250 abstract "Jellyfish and sea anemones fire single-use, venom-covered barbs to immobilize prey or predators. We previously showed that the anemone Nematostella vectensis uses a specialized voltage-gated calcium (CaV) channel to trigger stinging in response to synergistic prey-derived chemicals and touch (Weir et al., 2020). Here we use experiments and theory to find that stinging behavior is suited to distinct ecological niches. We find that the burrowing anemone Nematostella uses uniquely strong CaV inactivation for precise control of predatory stinging. In contrast, the related anemone Exaiptasia diaphana inhabits exposed environments to support photosynthetic endosymbionts. Consistent with its niche, Exaiptasia indiscriminately stings for defense and expresses a CaV splice variant that confers weak inactivation. Chimeric analyses reveal that CaVβ subunit adaptations regulate inactivation, suggesting an evolutionary tuning mechanism for stinging behavior. These findings demonstrate how functional specialization of ion channel structure contributes to distinct organismal behavior." @default.
- W4383217250 created "2023-07-06" @default.
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- W4383217250 date "2023-09-26" @default.
- W4383217250 modified "2023-10-16" @default.
- W4383217250 title "Molecular tuning of sea anemone stinging" @default.
- W4383217250 doi "https://doi.org/10.7554/elife.88900" @default.
- W4383217250 hasPublicationYear "2023" @default.
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