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- W4383218099 abstract "Jellyfish and sea anemones fire single-use, venom-covered barbs to immobilize prey or predators. We previously showed that the anemone Nematostella vectensis uses a specialized voltage-gated calcium (CaV) channel to trigger stinging in response to synergistic prey-derived chemicals and touch . Here we use experiments and theory to find that stinging behavior is suited to distinct ecological niches. We find that the burrowing anemone Nematostella uses uniquely strong CaV inactivation for precise control of predatory stinging. In contrast, the related anemone Exaiptasia diaphana inhabits exposed environments to support photosynthetic endosymbionts. Consistent with its niche, Exaiptasia indiscriminately stings for defense and expresses a CaV splice variant that confers weak inactivation. Chimeric analyses reveal that CaVβ subunit adaptations regulate inactivation, suggesting an evolutionary tuning mechanism for stinging behavior. These findings demonstrate how functional specialization of ion channel structure contributes to distinct organismal behavior." @default.
- W4383218099 created "2023-07-06" @default.
- W4383218099 creator A5024966374 @default.
- W4383218099 date "2023-07-05" @default.
- W4383218099 modified "2023-09-27" @default.
- W4383218099 title "eLife assessment: Molecular tuning of sea anemone stinging" @default.
- W4383218099 doi "https://doi.org/10.7554/elife.88900.1.sa0" @default.
- W4383218099 hasPublicationYear "2023" @default.
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