FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383218897> ?p ?o ?g. }

• W4383218897 endingPage "153588" @default.
• W4383218897 startingPage "153588" @default.
• W4383218897 abstract "The uncharged 3-hydroxy-2-pyridine aldoximes with protonatable tertiary amines are studied as antidotes in toxic organophosphates (OP) poisoning. Due to some of their specific structural features, we hypothesize that these compounds could exert diverse biological activity beyond their main scope of application. To examine this further, we performed an extensive cell-based assessment to determine their effects on human cells (SH-SY5Y, HEK293, HepG2, HK-2, myoblasts and myotubes) and possible mechanism of action. As our results indicated, aldoxime having a piperidine moiety did not induce significant toxicity up to 300 µM within 24 h, while those with a tetrahydroisoquinoline moiety, in the same concentration range, showed time-dependent effects and stimulated mitochondria-mediated activation of the intrinsic apoptosis pathway through ERK1/2 and p38-MAPK signaling and subsequent activation of initiator caspase 9 and executive caspase 3 accompanied with DNA damage as observed already after 4 h exposure. Mitochondria and fatty acid metabolism were also likely targets of 3-hydroxy-2-pyridine aldoximes with tetrahydroisoquinoline moiety, due to increased phosphorylation of acetyl-CoA carboxylase. In silico analysis predicted kinases as their most probable target class, while pharmacophores modeling additionally predicted the inhibition of a cytochrome P450cam. Overall, if the absence of significant toxicity for piperidine bearing aldoxime highlights the potential of its further studies in medical counter-measures, the observed biological activity of aldoximes with tetrahydroisoquinoline moiety could be indicative for future design of compounds either in a negative context in OP antidotes design, or in a positive one for design of compounds for the treatment of other phenomena like cell proliferating malignancies." @default.
• W4383218897 created "2023-07-06" @default.
• W4383218897 creator A5002489151 @default.
• W4383218897 creator A5005504175 @default.
• W4383218897 creator A5008386643 @default.
• W4383218897 creator A5013069107 @default.
• W4383218897 creator A5024791484 @default.
• W4383218897 creator A5029091802 @default.
• W4383218897 creator A5040851683 @default.
• W4383218897 creator A5062194631 @default.
• W4383218897 creator A5073108236 @default.
• W4383218897 creator A5075440909 @default.
• W4383218897 creator A5080040545 @default.
• W4383218897 creator A5083228737 @default.
• W4383218897 creator A5083459017 @default.
• W4383218897 creator A5088255464 @default.
• W4383218897 date "2023-08-01" @default.
• W4383218897 modified "2023-10-01" @default.
• W4383218897 title "Biological response and cell death signaling pathways modulated by tetrahydroisoquinoline-based aldoximes in human cells" @default.
• W4383218897 cites W1745634660 @default.
• W4383218897 cites W1935354256 @default.
• W4383218897 cites W1967939624 @default.
• W4383218897 cites W1968073114 @default.
• W4383218897 cites W1971513938 @default.
• W4383218897 cites W1979828510 @default.
• W4383218897 cites W1988838635 @default.
• W4383218897 cites W1993138129 @default.
• W4383218897 cites W1993827880 @default.
• W4383218897 cites W1994311414 @default.
• W4383218897 cites W1994682335 @default.
• W4383218897 cites W2006360771 @default.
• W4383218897 cites W2018672336 @default.
• W4383218897 cites W2030316086 @default.
• W4383218897 cites W2032417894 @default.
• W4383218897 cites W2060395692 @default.
• W4383218897 cites W2060657770 @default.
• W4383218897 cites W2062427160 @default.
• W4383218897 cites W2062683863 @default.
• W4383218897 cites W2063473618 @default.
• W4383218897 cites W2069842740 @default.
• W4383218897 cites W2074682587 @default.
• W4383218897 cites W2077060302 @default.
• W4383218897 cites W2077697175 @default.
• W4383218897 cites W2080251363 @default.
• W4383218897 cites W2088405210 @default.
• W4383218897 cites W2089569398 @default.
• W4383218897 cites W2098118571 @default.
• W4383218897 cites W2109019114 @default.
• W4383218897 cites W2134580783 @default.
• W4383218897 cites W2144099695 @default.
• W4383218897 cites W2156257249 @default.
• W4383218897 cites W2157672704 @default.
• W4383218897 cites W2163762710 @default.
• W4383218897 cites W2188280065 @default.
• W4383218897 cites W2229940530 @default.
• W4383218897 cites W2294909562 @default.
• W4383218897 cites W2401296772 @default.
• W4383218897 cites W2568545653 @default.
• W4383218897 cites W2586473870 @default.
• W4383218897 cites W2590560529 @default.
• W4383218897 cites W2593436234 @default.
• W4383218897 cites W2610328326 @default.
• W4383218897 cites W2799718726 @default.
• W4383218897 cites W2889562604 @default.
• W4383218897 cites W2904739103 @default.
• W4383218897 cites W2946412700 @default.
• W4383218897 cites W3006218643 @default.
• W4383218897 cites W3008093510 @default.
• W4383218897 cites W3033401203 @default.
• W4383218897 cites W3095243327 @default.
• W4383218897 cites W3129102316 @default.
• W4383218897 cites W3175292435 @default.
• W4383218897 cites W3175899028 @default.
• W4383218897 cites W3198291052 @default.
• W4383218897 doi "https://doi.org/10.1016/j.tox.2023.153588" @default.
• W4383218897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37419273" @default.
• W4383218897 hasPublicationYear "2023" @default.
• W4383218897 type Work @default.
• W4383218897 citedByCount "0" @default.
• W4383218897 crossrefType "journal-article" @default.
• W4383218897 hasAuthorship W4383218897A5002489151 @default.
• W4383218897 hasAuthorship W4383218897A5005504175 @default.
• W4383218897 hasAuthorship W4383218897A5008386643 @default.
• W4383218897 hasAuthorship W4383218897A5013069107 @default.
• W4383218897 hasAuthorship W4383218897A5024791484 @default.
• W4383218897 hasAuthorship W4383218897A5029091802 @default.
• W4383218897 hasAuthorship W4383218897A5040851683 @default.
• W4383218897 hasAuthorship W4383218897A5062194631 @default.
• W4383218897 hasAuthorship W4383218897A5073108236 @default.
• W4383218897 hasAuthorship W4383218897A5075440909 @default.
• W4383218897 hasAuthorship W4383218897A5080040545 @default.
• W4383218897 hasAuthorship W4383218897A5083228737 @default.
• W4383218897 hasAuthorship W4383218897A5083459017 @default.
• W4383218897 hasAuthorship W4383218897A5088255464 @default.
• W4383218897 hasConcept C185592680 @default.
• W4383218897 hasConcept C202751555 @default.
• W4383218897 hasConcept C2776120743 @default.
• W4383218897 hasConcept C2776406546 @default.

• next