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Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383220088> ?p ?o ?g. }

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• W4383220088 abstract "Photodynamic inhibition (PDI) of bacteria represents a powerful strategy for dealing with multidrug-resistant pathogens and infections, as it exhibits minimal development of antibiotic resistance. The PDI action stems from the generation of a triplet state in the photosensitizer (PS), which subsequently transfers energy or electrons to molecular oxygen, resulting in the formation of reactive oxygen species (ROS). These ROS are then able to damage cells, eventually causing bacterial eradication. Enhancing the efficacy of PDI includes the introduction of heavy atoms to augment triplet generation in the PS, as well as membrane intercalation to circumvent the problem of the short lifetime of ROS. However, the former approach can pose safety and environmental concerns, while achieving stable membrane partitioning remains challenging due to the complex outer envelope of bacteria. Here, we introduce a novel PS, consisting of a metal-free donor-acceptor thiophene-based conjugate molecule (BV-1). It presents several advantageous features for achieving effective PDI, namely: (i) it exhibits strong light absorption due to the conjugated donor-acceptor moieties; (ii) it exhibits spontaneous and stable membrane partitioning thanks to its amphiphilicity, accompanied by a strong fluorescence turn-on; (iii) it undergoes metal-free intersystem crossing, which occurs preferentially when the molecule resides in the membrane. All these properties, which we rationalized via optical spectroscopies and calculations, enable the effective eradication of Escherichia coli, with an inhibition concentration that is below that of current state-of-the-art treatments. Our approach holds significant potential for the development of new PS for controlling bacterial infections, particularly those caused by Gram-negative bacteria." @default.
• W4383220088 created "2023-07-06" @default.
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• W4383220088 date "2023-01-01" @default.
• W4383220088 modified "2023-10-16" @default.
• W4383220088 title "A membrane intercalating metal-free conjugated organic photosensitizer for bacterial photodynamic inactivation" @default.
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• W4383220088 doi "https://doi.org/10.1039/d3sc01168b" @default.
• W4383220088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37538813" @default.
• W4383220088 hasPublicationYear "2023" @default.
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