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- W4383224595 abstract "Fibrosis, or excessive scarring, is characterized by the emergence of alpha-smooth muscle actin (αSMA)-expressing myofibroblasts and the excessive accumulation of fibrotic extracellular matrix (ECM). Currently, there is a lack of effective treatment options for fibrosis, highlighting an unmet need to identify new therapeutic targets. The acquisition of a fibrotic phenotype is associated with changes in chromatin structure, a key determinant of gene transcription activation and repression. The major repressive histone mark, H3K27me3, has been linked to dynamic changes in gene expression in fibrosis through alterations in chromatin structure. H3K27-specific homologous histone methylase (HMT) enzymes, Enhancer of zeste 1 and 2 (EZH1, EZH2), which are the alternative subunits of the Polycomb Repressive Complex 2 (PRC2) and demethylase (KDM) enzymes, Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), and Lysine demethylase 6B (KDM6B), are responsible for regulating methylation status of H3K27me3. In this review, we explore how these key enzymes regulate chromatin structure to alter gene expression in fibrosis, highlighting them as attractive targets for the treatment of fibrosis." @default.
- W4383224595 created "2023-07-06" @default.
- W4383224595 creator A5009584148 @default.
- W4383224595 creator A5015697414 @default.
- W4383224595 creator A5034585863 @default.
- W4383224595 creator A5060073633 @default.
- W4383224595 date "2023-07-05" @default.
- W4383224595 modified "2023-09-25" @default.
- W4383224595 title "Fibrosis—the tale of H3K27 histone methyltransferases and demethylases" @default.
- W4383224595 cites W1484016032 @default.
- W4383224595 cites W1588127651 @default.
- W4383224595 cites W1909516796 @default.
- W4383224595 cites W1967183293 @default.
- W4383224595 cites W1970779494 @default.
- W4383224595 cites W1971561248 @default.
- W4383224595 cites W1972231534 @default.
- W4383224595 cites W1975318062 @default.
- W4383224595 cites W1978182359 @default.
- W4383224595 cites W1980098393 @default.
- W4383224595 cites W1980255776 @default.
- W4383224595 cites W2009036920 @default.
- W4383224595 cites W2013537969 @default.
- W4383224595 cites W2014182371 @default.
- W4383224595 cites W2016015848 @default.
- W4383224595 cites W2025856640 @default.
- W4383224595 cites W2026639078 @default.
- W4383224595 cites W2045171767 @default.
- W4383224595 cites W2046755222 @default.
- W4383224595 cites W2048035811 @default.
- W4383224595 cites W2050083560 @default.
- W4383224595 cites W2051329702 @default.
- W4383224595 cites W2058278041 @default.
- W4383224595 cites W2059114286 @default.
- W4383224595 cites W2060290432 @default.
- W4383224595 cites W2061925865 @default.
- W4383224595 cites W2077888205 @default.
- W4383224595 cites W2078052857 @default.
- W4383224595 cites W2083837059 @default.
- W4383224595 cites W2086554513 @default.
- W4383224595 cites W2087814592 @default.
- W4383224595 cites W2088711557 @default.
- W4383224595 cites W2091491022 @default.
- W4383224595 cites W2094051261 @default.
- W4383224595 cites W2098638123 @default.
- W4383224595 cites W2098765934 @default.
- W4383224595 cites W2103170336 @default.
- W4383224595 cites W2116053081 @default.
- W4383224595 cites W2121596297 @default.
- W4383224595 cites W2123002130 @default.
- W4383224595 cites W2132194624 @default.
- W4383224595 cites W2141520345 @default.
- W4383224595 cites W2142278869 @default.
- W4383224595 cites W2149072783 @default.
- W4383224595 cites W2159202892 @default.
- W4383224595 cites W2161179853 @default.
- W4383224595 cites W2164052369 @default.
- W4383224595 cites W2164113977 @default.
- W4383224595 cites W2170639077 @default.
- W4383224595 cites W2230411827 @default.
- W4383224595 cites W2337844847 @default.
- W4383224595 cites W2342679639 @default.
- W4383224595 cites W2397597082 @default.
- W4383224595 cites W2418343927 @default.
- W4383224595 cites W2419237034 @default.
- W4383224595 cites W2510537516 @default.
- W4383224595 cites W2546708985 @default.
- W4383224595 cites W2551265267 @default.
- W4383224595 cites W2567957521 @default.
- W4383224595 cites W2597669146 @default.
- W4383224595 cites W2601682232 @default.
- W4383224595 cites W2602604359 @default.
- W4383224595 cites W2606492372 @default.
- W4383224595 cites W2607311200 @default.
- W4383224595 cites W2614568617 @default.
- W4383224595 cites W2762080276 @default.
- W4383224595 cites W2763979543 @default.
- W4383224595 cites W2765457228 @default.
- W4383224595 cites W2767137153 @default.
- W4383224595 cites W2781527068 @default.
- W4383224595 cites W2781934183 @default.
- W4383224595 cites W2803683223 @default.
- W4383224595 cites W2807105819 @default.
- W4383224595 cites W2811470808 @default.
- W4383224595 cites W2888261125 @default.
- W4383224595 cites W2889974697 @default.
- W4383224595 cites W2896191013 @default.
- W4383224595 cites W2897312013 @default.
- W4383224595 cites W2902678397 @default.
- W4383224595 cites W2905418336 @default.
- W4383224595 cites W2910931852 @default.
- W4383224595 cites W2914617610 @default.
- W4383224595 cites W2933260868 @default.
- W4383224595 cites W2936662327 @default.
- W4383224595 cites W2946016316 @default.
- W4383224595 cites W2946676989 @default.
- W4383224595 cites W2948083294 @default.
- W4383224595 cites W2967839367 @default.
- W4383224595 cites W2968643140 @default.
- W4383224595 cites W2978340682 @default.
- W4383224595 cites W2985676661 @default.