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• W4383226360 abstract "The aim of the present study was to perform the accurate prognosis of different molecular types breast cancer (BC) by using the partitioning calculation method of the Ki‑67 index. Partitioning calculation was used to judge the Ki‑67 index and the molecular type was classified according to the 2019 Chinese Society of Clinical Oncology guidelines in 199 cases of BC. The association between the Ki‑67 index and overall survival (OS), disease‑free survival (DFS) and molecular types was analyzed using the Chi‑squared test. Survival analysis was performed using the Kaplan‑Meier method with statistical SPSS 18.0 software. The results revealed that the 5‑year survival rate of patients with BC was 18.60% (8/43), the 6‑year survival rate was 38.24% (26/68), while the 10‑year survival rate of patients with BC was 73.08% (133/182); the results indicated that almost 80% patients succumbed during the 5 years following diagnosis. Marked differences were found between the OS of patients with BC and the Ki‑67 index (between 50 to 54%) (χ²=4.83, P=0.028; χ²=4.60, P=0.032 respectively). All 14 cases of luminal A subtype BC with a Ki‑67 index ≤4% survived at the end of follow‑up time (69‑156 months). At the same time, there was a marked difference between two groups of patients with overexpression HER‑2 while using 50% as a cut‑off point of Ki‑67 (χ²=5.54, P=0.019). On the whole, the present study demonstrates that the partitioning calculation of the Ki‑67 index can be used to judge the prognosis of patients with BC accurately. The prognosis of patients with different molecular subtypes of BC may be associated with the different Ki‑67 index." @default.
• W4383226360 created "2023-07-06" @default.
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• W4383226360 date "2023-07-05" @default.
• W4383226360 modified "2023-09-27" @default.
• W4383226360 title "Accurate prognosis of patients with luminal type A and HER‑2 overexpressing breast cancer via the partitioning calculation method of the Ki‑67 index" @default.
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• W4383226360 doi "https://doi.org/10.3892/wasj.2023.198" @default.
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