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- W4383226840 endingPage "166802" @default.
- W4383226840 startingPage "166802" @default.
- W4383226840 abstract "In vivo and in vitro studies demonstrate that mitochondria in the oocyte, are susceptible to damage by suboptimal pre/pregnancy conditions, such as obesity. These suboptimal conditions have been shown to induce mitochondrial dysfunction (MD) in multiple tissues of the offspring, suggesting that mitochondria of oocytes that pass from mother to offspring, can carry information that can programme mitochondrial and metabolic dysfunction of the next generation. They also suggest that transmission of MD could increase the risk of obesity and other metabolic diseases in the population inter- and trans-generationally. In this review, we examined whether MD observed in offspring tissues of high energetic demand, is the result of the transmission of damaged mitochondria from the oocytes of obese mothers to the offspring. The contribution of genome-independent mechanisms (namely mitophagy) in this transmission were also explored. Finally, potential interventions aimed at improving oocyte/embryo health were investigated, to see if they may provide an opportunity to halter the generational effects of MD." @default.
- W4383226840 created "2023-07-06" @default.
- W4383226840 creator A5030016409 @default.
- W4383226840 creator A5051866717 @default.
- W4383226840 creator A5075300811 @default.
- W4383226840 date "2023-10-01" @default.
- W4383226840 modified "2023-10-16" @default.
- W4383226840 title "Mitochondrial dysfunction in the offspring of obese mothers and it's transmission through damaged oocyte mitochondria: Integration of mechanisms" @default.
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