Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383265722> ?p ?o ?g. }
- W4383265722 endingPage "571" @default.
- W4383265722 startingPage "563" @default.
- W4383265722 abstract "Whereas progress has been made in the identification of neural signals related to rapid, cued decisions1-3, less is known about how brains guide and terminate more ethologically relevant decisions in which an animal's own behaviour governs the options experienced over minutes4-6. Drosophila search for many seconds to minutes for egg-laying sites with high relative value7,8 and have neurons, called oviDNs, whose activity fulfills necessity and sufficiency criteria for initiating the egg-deposition motor programme9. Here we show that oviDNs express a calcium signal that (1) dips when an egg is internally prepared (ovulated), (2) drifts up and down over seconds to minutes-in a manner influenced by the relative value of substrates-as a fly determines whether to lay an egg and (3) reaches a consistent peak level just before the abdomen bend for egg deposition. This signal is apparent in the cell bodies of oviDNs in the brain and it probably reflects a behaviourally relevant rise-to-threshold process in the ventral nerve cord, where the synaptic terminals of oviDNs are located and where their output can influence behaviour. We provide perturbational evidence that the egg-deposition motor programme is initiated once this process hits a threshold and that subthreshold variation in this process regulates the time spent considering options and, ultimately, the choice taken. Finally, we identify a small recurrent circuit that feeds into oviDNs and show that activity in each of its constituent cell types is required for laying an egg. These results argue that a rise-to-threshold process regulates a relative-value, self-paced decision and provide initial insight into the underlying circuit mechanism for building this process." @default.
- W4383265722 created "2023-07-06" @default.
- W4383265722 creator A5013474373 @default.
- W4383265722 creator A5015971901 @default.
- W4383265722 creator A5018533362 @default.
- W4383265722 creator A5030832398 @default.
- W4383265722 creator A5039360877 @default.
- W4383265722 creator A5046117659 @default.
- W4383265722 creator A5073647061 @default.
- W4383265722 creator A5091823450 @default.
- W4383265722 date "2023-07-05" @default.
- W4383265722 modified "2023-10-14" @default.
- W4383265722 title "A rise-to-threshold process for a relative-value decision" @default.
- W4383265722 cites W1491075702 @default.
- W4383265722 cites W1540070193 @default.
- W4383265722 cites W1562764236 @default.
- W4383265722 cites W1595045726 @default.
- W4383265722 cites W1965647411 @default.
- W4383265722 cites W1965953864 @default.
- W4383265722 cites W1969558625 @default.
- W4383265722 cites W1977675569 @default.
- W4383265722 cites W1980820144 @default.
- W4383265722 cites W1980871601 @default.
- W4383265722 cites W1981330394 @default.
- W4383265722 cites W1982121456 @default.
- W4383265722 cites W1995542880 @default.
- W4383265722 cites W1997173667 @default.
- W4383265722 cites W1997958161 @default.
- W4383265722 cites W2009380617 @default.
- W4383265722 cites W2019754186 @default.
- W4383265722 cites W2025654941 @default.
- W4383265722 cites W2028568903 @default.
- W4383265722 cites W2035424802 @default.
- W4383265722 cites W2040707073 @default.
- W4383265722 cites W2045919956 @default.
- W4383265722 cites W2048524988 @default.
- W4383265722 cites W2049127221 @default.
- W4383265722 cites W2057699169 @default.
- W4383265722 cites W2058082904 @default.
- W4383265722 cites W2076546992 @default.
- W4383265722 cites W2077208091 @default.
- W4383265722 cites W2077611535 @default.
- W4383265722 cites W2081092282 @default.
- W4383265722 cites W2102033338 @default.
- W4383265722 cites W2108144145 @default.
- W4383265722 cites W2111531146 @default.
- W4383265722 cites W2112191288 @default.
- W4383265722 cites W2117794907 @default.
- W4383265722 cites W2123233139 @default.
- W4383265722 cites W2135563396 @default.
- W4383265722 cites W2135710940 @default.
- W4383265722 cites W2137700545 @default.
- W4383265722 cites W2144095870 @default.
- W4383265722 cites W2151308847 @default.
- W4383265722 cites W2169134378 @default.
- W4383265722 cites W2219709225 @default.
- W4383265722 cites W2345390633 @default.
- W4383265722 cites W2481995903 @default.
- W4383265722 cites W2567727905 @default.
- W4383265722 cites W2570782440 @default.
- W4383265722 cites W2580319655 @default.
- W4383265722 cites W2594700647 @default.
- W4383265722 cites W2611542631 @default.
- W4383265722 cites W2614915054 @default.
- W4383265722 cites W2746729273 @default.
- W4383265722 cites W2760856044 @default.
- W4383265722 cites W2765577635 @default.
- W4383265722 cites W2779759428 @default.
- W4383265722 cites W2785502402 @default.
- W4383265722 cites W2794689995 @default.
- W4383265722 cites W2802004087 @default.
- W4383265722 cites W2805271873 @default.
- W4383265722 cites W2887114371 @default.
- W4383265722 cites W2910164934 @default.
- W4383265722 cites W2947296851 @default.
- W4383265722 cites W2950418175 @default.
- W4383265722 cites W2950849463 @default.
- W4383265722 cites W2950866057 @default.
- W4383265722 cites W2965956202 @default.
- W4383265722 cites W2989785130 @default.
- W4383265722 cites W2991078956 @default.
- W4383265722 cites W2991987583 @default.
- W4383265722 cites W3008543536 @default.
- W4383265722 cites W3016007634 @default.
- W4383265722 cites W3043725759 @default.
- W4383265722 cites W3093848977 @default.
- W4383265722 cites W3132801442 @default.
- W4383265722 cites W3194760871 @default.
- W4383265722 cites W4200186209 @default.
- W4383265722 cites W4200478016 @default.
- W4383265722 cites W4286208813 @default.
- W4383265722 cites W4286851579 @default.
- W4383265722 cites W4293242931 @default.
- W4383265722 cites W4307475658 @default.
- W4383265722 cites W4377290341 @default.
- W4383265722 doi "https://doi.org/10.1038/s41586-023-06271-6" @default.
- W4383265722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37407812" @default.
- W4383265722 hasPublicationYear "2023" @default.